Platelet aggregation induced by 1-desamino-8-D-arginine vasopressin (DDAVP) in Type IIB von Willebrand's disease

The New England Journal of Medicine
L HolmbergE Sjörin

Abstract

Type IIB von Willebrand's disease is a distinct form of this disorder, in which there are abnormal factor VIII/von Willebrand factor multimers in plasma (but normal multimers in platelets) and heightened interaction between the von Willebrand factor and platelets in the presence of ristocetin. We have found that infusion of desmopressin acetate (1-desamino-8-D-arginine vasopressin [DDAVP]), an agent used in the treatment of von Willebrand's disease, causes platelet aggregation and thrombocytopenia in patients with Type IIB disease. In vitro, platelets in normal plasma and those obtained from patients with Type IIB disease before DDAVP infusion aggregated upon the addition of platelet-poor plasma from Type IIB patients treated with DDAVP. Platelet aggregation was associated with adsorption of multimers of factor VIII/von Willebrand factor onto the platelets and was inhibited by EDTA. We conclude that in Type IIB von Willebrand's disease, DDAVP releases an abnormal factor with platelet-aggregating properties. DDAVP should not be used to treat patients with Type IIB disease, since the presence of platelet aggregates in the circulation may be harmful.

References

Apr 1, 1978·Thrombosis Research·L Holmberg, R Ljung
Jun 1, 1977·British Journal of Haematology·P N WalshJ G White
Jan 1, 1974·Thrombosis Research·J A van MourikI A Mochtar
Mar 1, 1973·The American Journal of the Medical Sciences·M P CorderO Barrett
Jan 1, 1974·Scandinavian Journal of Haematology·L Holmberg, I M Nilsson
Jan 1, 1968·Scandinavian Journal of Haematology·S Cronberg, I M Nilsson
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·Z M RuggeriL de Marco
Jul 1, 1982·Scandinavian Journal of Haematology·I M NilssonH Vilhardt
Nov 1, 1982·The Journal of Clinical Investigation·Z M RuggeriT S Zimmerman
Sep 1, 1981·Scandinavian Journal of Haematology·S B SundqvistS Cronberg

❮ Previous
Next ❯

Citations

Oct 1, 1994·Annals of Hematology·S Lethagen
Jan 8, 1999·International Journal of Clinical & Laboratory Research·P M Mannucci
Jul 1, 1990·European Journal of Obstetrics, Gynecology, and Reproductive Biology·F A ValsterJ W Hutten
Apr 29, 1993·Regulatory Peptides·J L David
Apr 1, 1996·Transfusion Medicine Reviews·E W Murray, D Lillicrap
Jan 5, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·P M Mannucci
Jan 22, 2005·Seminars in Hematology·Francesco Rodeghiero, Giancarlo Castaman
Mar 15, 1984·The New England Journal of Medicine·H TakahashiA Shibata
Aug 13, 2004·The New England Journal of Medicine·Pier Mannuccio Mannucci
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·K A CooneyD Ginsburg
Jan 1, 1997·Medicine·W C Nichols, D Ginsburg
Mar 7, 2002·Current Opinion in Pediatrics·Augusto B Federici, Pier Mannuccio Mannucci
Oct 24, 2002·Current Opinion in Hematology·Jason ChiuThomas J Reid
Jul 14, 2005·Journal of Pediatric Hematology/oncology·Lawrence S AmesseJames A French
Nov 14, 1987·Schweizerische medizinische Wochenschrift·M Furlan
Dec 1, 1991·British Journal of Haematology·H R GralnickM Vail
Aug 1, 1990·Australian and New Zealand Journal of Medicine·T ExnerE Berry
Jan 1, 1997·Annual Review of Medicine·B M Ewenstein
Jan 22, 2005·Annual Review of Medicine·J Evan Sadler
Mar 19, 2011·Journal of the American Society of Nephrology : JASN·Wiebke FenskeUNKNOWN German Diabetes, Dialysis Study Investigators
Jan 24, 2015·Hämostaseologie·Z M Ruggeri, G L Mendolicchio
Jun 1, 1987·Baillière's Clinical Haematology·J A Copplestone
Jul 1, 1989·Baillière's Clinical Haematology·D BaruchD Meyer
May 1, 1988·British Journal of Haematology·P A KyrleK Lechner
Oct 19, 2013·Blood·Giancarlo Castaman
Nov 1, 2001·Best Practice & Research. Clinical Haematology·P M Mannucci, A B Federici
Jan 1, 1998·Hematology·P M Mannucci

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.