PMID: 8456091Jan 1, 1993Paper

Platelet aggregation inhibiting activity of human placental chorioepithelial brush border membrane vesicles

Placenta
H IiokaM Ichijo

Abstract

We investigated the platelet aggregation inhibiting activity of human placental brush border membrane vesicles (BBMV) and obtained the following results. A strong platelet aggregation inhibiting activity existed in placental BBMV. The BBMV inhibited the platelet aggregation induced by ADP, arachidonic acid, collagen and ristocetin in a dose-dependent manner. The protein concentration of BBMV giving 50 per cent inhibition was 52 +/- 6 micrograms/ml for ADP-induced platelet aggregation, 21 +/- 2 micrograms/ml for arachidonic acid-induced platelet aggregation, 19 +/- 2 micrograms/ml for collagen-induced platelet aggregation and 107 +/- 9 micrograms/ml for ristocetin-induced platelet aggregation. There was a high level of ADP degrading activity (ADPase activity) in the placental BBMV. ADP degrading activity of the BBMV: 10.5 +/- 0.5 mumol/mg protein/min was 21 times greater than that of homogenate of the placental villi. The placental BBMV inhibited platelet TXA2 production. In the 40 micrograms/ml protein concentration of placental BBMV, platelet TXA2 production was almost completely inhibited.

References

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Citations

Sep 30, 1994·Annals of the New York Academy of Sciences·J N Bulmer
Oct 28, 2011·FEMS Microbiology Letters·Cai YongjunZou Goulin
Jan 1, 1994·Platelets·W W BakkerD P Mikhailidis

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