Platelet alloantigens HPA-1, -2, -3, -5 and -6b in Finns.

Transfusion Medicine
S KekomäkiR Kekomäki

Abstract

The human platelet alloantigens HPA-1, -2, -3, -5 and -6b in the Finnish population were determined using allele specific restriction analysis (PCR-ASRA) for HPA-1, -2, -3 and -5 and monoclonal antibody immobilized platelet antigen (MAIPA) assay for HPA-1, -3a, -5b and -6b. No discrepancies were observed between the results obtained with the PCR-method and those obtained serologically. The gene frequencies obtained from 200 unrelated Finns were 0.86 and 0.14 for HPA-1a and -1b, 0.91 and 0.09 for HPA-2a and -2b, 0.59 and 0.41 for HPA-3a and -3b and 0.95 and 0.05 for HPA-5a and -5b. The frequency of the HPA-5b allele (10%) is lower in Finns than in Central- or South-European populations (20-30%). The HPA-1, -2 and -3 frequencies did not deviate from those observed in other European populations. The rare HPA-6b antigen was observed in three of 127 individuals from south-eastern Finland (2.4%), which suggests that the frequency of this allele in Finland is higher than previously thought.

References

Sep 1, 1992·Transfusion Medicine·V Kiefel
Apr 1, 1990·Transfusion Medicine Reviews·C Mueller-EckhardtS Santoso
Feb 6, 1990·Biochemistry·R HeidenreichM Poncz
Jan 1, 1986·Vox Sanguinis·C ProwseY Waterston
Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Jan 1, 1994·Tissue Antigens·P MercierD Reviron
Jun 1, 1993·Transfusion Medicine·B R AndersenA Svejgaard
Sep 1, 1993·Transfusion·S SantosoC Mueller-Eckhardt
May 1, 1961·Annals of Human Genetics·R D KOLER, D A RIGAS

❮ Previous
Next ❯

Citations

Mar 11, 2000·Obstetrics and Gynecology·S SainioR Kekomäki
Oct 12, 2000·Journal of the American College of Cardiology·J MikkelssonP J Karhunen
Sep 17, 1999·Tissue Antigens·N MojaatC Kaplan
Jan 9, 1999·Transfusion Medicine·K DrzewekB Zupańska
Dec 3, 1999·Transfusion Medicine·S SainioR Kekomäki
Apr 23, 2002·Transfusion Medicine·G FerrerA Baali
Aug 1, 1996·Tissue Antigens·R SteffensenC Jersild
Aug 15, 1998·Vox Sanguinis·H KrollS Santoso
Apr 30, 2005·Transfusion Medicine·B KulkarniK Ghosh
Dec 17, 2003·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·D C JonesS E Marshall
Dec 11, 2007·Transfusion Medicine·A S SabbaghR A R Mahfouz
Apr 11, 2008·Transfusion Medicine·C D De La Vega ElenaE Muñiz-Díaz
Sep 26, 2009·Transfusion Medicine·M PavicS Dodig
Mar 15, 2005·Hematology·W N ErberT J Threlfall
Aug 17, 2016·Transfusion Medicine·C N PortelaS S Weber
Oct 4, 2016·Transfusion Medicine·R PhuangthamA V Romphruk
Dec 20, 1999·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·V CastroV R Arruda
Dec 3, 1999·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·J SellersC Darke
Jan 29, 2005·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Viroj Wiwanitkit
Apr 1, 2006·Tissue Antigens·M PavkovicM Spiroski
May 16, 1998·Tissue Antigens·Y W ChangB R Hawkins
Aug 24, 1999·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·P RozmanF H Claas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.