Platelet and leukocyte activation during aortoiliac angiography and angioplasty

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
J BaraniB Lindblad

Abstract

to evaluate platelet and leukocyte activation during aortoiliac angiography and percutaneous transluminal angioplasty (PTA). an observational study of 14 patients with aortoiliac atherosclerotic disease, nine of whom underwent PTA. The proportion of fibrinogen-, and P-selectin positive platelets, P-selectin expression on platelets, intraplatelet cGMP and cAMP, CD18 positive granulocytes, CD18 expression on granulocytes, plasma (p)-neopterin, p-TNF alpha and p- interleukin-6 were repeatedly measured in arterial blood during angiography and in venous blood before and after. compared to a previous venous sample, arterial intraplatelet cAMP was increased proximal to the atherosclerotic lesion before contrast infusion and PTA (median 18 [range: 14-22] vs 16 [15-21] pmol/10(9) platelets p<0.05), and intraplatelet cGMP was increased proximal to the lesion after contrast infusion and PTA (1.2 [0.8-3.9] vs 0.9 [0.6-2.5] pmol/10(9) platelets p<0.05). Four hours after angiography, both the proportion of P-selectin positive platelets (28[11-55]%) and platelet P-selectin expression (9[6-40]) had decreased (p<0.05), from arterial values distal to the lesion before contrast infusion and PTA (57 [24-78]% and 26 [10-83]). Granulocyte CD18 expre...Continue Reading

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Citations

Jan 6, 2006·European Radiology·Peter AspelinUNKNOWN Members of the Contrast Media Safety Committee of the European Society of Urogenital Radiology (ESUR)
Jun 17, 2006·Atherosclerosis·Richard S YoungShervanthi Homer-Vanniasinkam
Jul 5, 2003·Journal of Vascular Surgery·K CassarJ Brittenden
Mar 8, 2003·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·R J HinchliffeB R Hopkinson
Sep 27, 2003·Acta Radiologica·W K Laskey, J Gellman

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