Platelet and vessel associated prostacyclin and thromboxane A2/prostaglandin endoperoxide receptors

European Journal of Clinical Investigation
K Jaschonek, C P Muller

Abstract

Synthetic stable analogues of thromboxane A2 (TXA2), cyclic endoperoxides (PGH2) and prostacyclin (PGI2) opened up new opportunities for investigating the mechanisms of action of these compounds. They proved to be useful pharmacological probes for characterizing PGI2 and TXA2/PGH2 receptors. Over the past few years, new synthetic antagonists with high specificity allowed the modulation of biological responses to endogenous eicosanoids. These compounds will, therefore, considerably promote our understanding of the biological function and significance of arachidonate metabolites. The present review summarizes current concepts that have arisen concerning platelet and vascular PGI2 and TXA2/PGH2 receptors, their transmembrane signal transduction, as well as their possible implications in the pathophysiology of cardiovascular disease.

References

Jul 1, 1975·Biochemistry·P G Kury, M McConnell
May 17, 1979·The New England Journal of Medicine·S Moncada, J R Vane
Sep 12, 1979·Biochemical and Biophysical Research Communications·A M SieglM J Silver
Jun 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·K C NicolaouA M Lefer
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G C Le BretonP V Halushka
Feb 1, 1979·The Journal of Clinical Investigation·A M SieglD Ahern
Dec 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·H Borochov, M Shinitzky
Mar 1, 1985·British Journal of Pharmacology·R A ArmstrongN H Wilson
Oct 15, 1986·Biochemical and Biophysical Research Communications·D E MaisP V Halushka
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R M BurchP V Halushka
Nov 15, 1985·Biochemical and Biophysical Research Communications·R M BurchP V Halushka
Feb 1, 1986·The Journal of Clinical Investigation·D J FitzgeraldG A FitzGerald
Aug 1, 1986·Journal of the American College of Cardiology·K JaschonekW Renn
Sep 1, 1986·Prostaglandins, Leukotrienes, and Medicine·K JaschonekH Weisenberger
Jan 20, 1987·European Journal of Pharmacology·C L Wainwright, J R Parratt
Jul 1, 1986·Journal of the American College of Cardiology·J T Shepherd, P M Vanhoutte
Oct 16, 1986·The New England Journal of Medicine·D J FitzgeraldG A FitzGerald
Jul 1, 1986·Journal of the American College of Cardiology·J T WillersonL M Buja
Dec 1, 1985·Circulation·G A FitzGeraldA K Pedersen
Dec 1, 1985·Circulation·B J Whittle, S Moncada
Nov 15, 1985·Thrombosis Research·S J IsraelsJ M Gerrard
Jan 23, 1974·Biochemical and Biophysical Research Communications·P G KuryH M McConnell
Sep 1, 1974·Thrombosis Research·D C Mills, D E Macfarlane
Aug 3, 1984·European Journal of Pharmacology·D N HarrisT E Steinbacher
Jun 1, 1984·The Biochemical Journal·M J Berridge
Jul 1, 1984·Prostaglandins, Leukotrienes, and Medicine·W C Horne
Oct 13, 1984·Lancet·G G Neri SerneriG F Gensini
Sep 1, 1980·Biochemical Pharmacology·E Schillinger, G Prior
Nov 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J R Dave, R A Knazek
Aug 1, 1983·British Journal of Pharmacology·R A ArmstrongN H Wilson
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·A M LeferK C Nicolaou
May 15, 1981·Biochemical and Biophysical Research Communications·R R GormanG L Bundy

Citations

Aug 6, 1992·European Journal of Pharmacology·S HenniesK F Sewing
May 15, 1995·European Journal of Pharmacology·H Parfenova, C W Leffler
Jan 1, 1990·Pharmacology & Therapeutics·G J Dusting, P S MacDonald
Nov 10, 2000·Biochemical and Biophysical Research Communications·V Ullrich, M Bachschmid
Sep 1, 1991·Medicinal Research Reviews·S E Hall
Feb 1, 1990·British Journal of Urology·P J RussellD Raghavan
May 31, 2002·Journal of Endocrinological Investigation·C UrsingS Röjdmark
Jun 5, 1998·The American Journal of Physiology·N WeissmannW Seeger

Related Concepts

Prostaglandin endoperoxide receptor
Cyclic AMP, (R)-Isomer
Adenylate Cyclase
Blood Platelets
Calcium
Cardiovascular Diseases
Hydrolysis
Ion Channel
Muscle, Smooth, Vascular
Phosphatidylinositols

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.