PMID: 9540947Apr 16, 1998Paper

Platelet angiotensin II binding sites and early detection of preeclampsia

Obstetrics and Gynecology
L PouliotJ Massé

Abstract

To determine if platelet angiotensin II binding density during the second or third trimester of pregnancy can be used as a marker for early detection of women who will develop preeclampsia. We collected blood samples from 412 nulliparous pregnant women during their second or third trimesters. They were classified in four groups after delivery: normotensive (n=297), transient hypertensive (n=54), preeclamptic (n=39), and chronic hypertensive (n=22). We also studied 35 nonpregnant women and 122 women in the peripartum period. The binding capacity of platelet angiotensin II receptors was analyzed in each patient. In normotensive pregnancies, there was a significant decrease in mean (+/-standard error of the mean [SEM]) platelet binding in the second trimester (1.6+/-0.2 fmol/10(9) cells) compared with nonpregnant women (3.3+/-0.7 fmol/10[9] cells). No statistical differences were observed in the mean (+/-SEM) number of platelet angiotensin II binding sites between the groups studied in the third trimester (normal: 1.7+/-0.1 fmol/10(9) cells; transient hypertensive: 2.3+/-0.4 fmol/10(9) cells; preeclamptic: 1.6+/-0.4 fmol/10(9) cells, and chronic hypertensive: 1.6+/-0.6 fmol/10(9) cells), nor were any significant differences found ...Continue Reading

References

Jul 1, 1991·American Journal of Obstetrics and Gynecology·G A Dekker, B M Sibai
May 1, 1991·British Journal of Obstetrics and Gynaecology·P N BakerE M Symonds
Jun 1, 1985·Journal of Hypertension·Y A DingP F Semple
Jan 15, 1985·American Journal of Obstetrics and Gynecology·J M MoutquinN Pelland
Nov 1, 1973·The Journal of Clinical Investigation·N F GantP C MacDonald
May 1, 1984·The Journal of Clinical Endocrinology and Metabolism·T J MooreG H Williams
Sep 1, 1993·American Journal of Obstetrics and Gynecology·J MasséM Bélanger

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Citations

Aug 10, 1999·Journal of Clinical Apheresis·K MahalatiJ N Martin
Sep 12, 2000·Current Hypertension Reports·R ShearJ M Moutquin
Mar 16, 2004·Seminars in Nephrology·Ursula QuittererSaid Abdalla
Feb 5, 1999·Obstetrics and Gynecology·P M O'BrienP W Jones
Apr 29, 1999·Current Opinion in Obstetrics & Gynecology·D O Anumba, S C Robson
Apr 12, 2002·Endocrine Reviews·Fernando M ReisFelice Petraglia

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