Platelet anti-aggregating triterpenoids from the leaves of Acanthopanax senticosus and the fruits of A. sessiliflorus

Planta medica
Jing Ling JinH S Yun-Choi

Abstract

Six triterpenoids, chiisanogenin, chiisanoside, ursolic acid, oleanolic acid, beta-sitosterol and daucosterol, were isolated as the platelet anti-aggregating components from the leaves of Acanthopanax senticosus and the fruits of A. sessiliflorus. Chiisanogenin showed about 50-fold higher potency than acetylsalicylic acid (ASA) on U46619-induced platelet aggregation (IC50o:6.21 microM) and 10-20-fold higher effects than ASA on epinephrine- and arachidonic acid (AA)-induced aggregation (IC50:2.50 and 4.81 microM, respectively).

Citations

Jul 3, 2007·Chemical & Pharmaceutical Bulletin·Fang LiKazuo Koike
Mar 9, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chun-Juan YangHai-Xue Kuang
Mar 10, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Claudia Alvarado-CastilloEdilmo Carvajal
Jul 11, 2014·Biomolecules & Therapeutics·Mikyung KimMoo-Yeol Lee
Aug 2, 2013·Experimental Animals·Jung-Hoon KimHong-Geun Oh
Oct 15, 2011·Journal of Ethnobiology and Ethnomedicine·Nima D NamsaSubhash C Mandal

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