PMID: 3752069Oct 1, 1986Paper

Platelet-associated immunoglobulins IgG, IgM, IgA and complement C3 in immune and nonimmune thrombocytopenic disorders

American Journal of Hematology
S PanzerC Mueller-Eckhardt

Abstract

A two-stage radioactive antiglobulin test--using unlabelled antisera specific for IgG, IgA, IgM and C3 followed by binding of 125I-staphylococcal protein A--was applied to determine platelet-associated immunoglobulins (PAIg) and complement (PAC3) in thrombocytopenias of various etiologies. One hundred and one patients with immune thrombocytopenia (chronic autoimmune, 48; acute autoimmune, 37; Evans syndrome, nine; connective tissue diseases, seven) and 20 patients with presumed nonimmune thrombocytopenia (bone marrow aplasia or malignancy, six; septicemia, five; hypersplenism, five; cirrhosis of liver, three; others, one) were studied. Increased levels of PAIg/C3 were found in 76% of patients with immune thrombocytopenia. PAIgG was raised in 66%, PAIgM in 57%, PAIgA in 44%, and PAC3 in 29%. Isolated elevation of PAIgG and of PAIgM was found in four and three cases, respectively; PAIgA and PAC3 were elevated in one case each. PAIgG was associated with PAIgM in 56%, with PAIgA in 34%, and with PAC3 in 27%. Both patients with Evans' syndrome and patients with connective tissue diseases had significantly higher PAIgM levels than the other patients with immune thrombocytopenia. In patients with nonimmune thrombocytopenia, increased ...Continue Reading

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Citations

Jun 3, 1999·Transfusion Science·M L Rand, J F Wright
Oct 18, 2006·European Journal of Haematology·Simon PanzerMarkus Peck-Radosavljevic
Sep 1, 1993·Clinical and Experimental Immunology·S NomuraM Yanabu
Mar 1, 1990·Acta paediatrica Scandinavica·M DonnérL Holmberg
May 1, 1993·The American Journal of the Medical Sciences·S FukudoA Hoshino
Aug 26, 2006·Pediatric Blood & Cancer·Simon PanzerIngrid Pabinger
Oct 1, 1991·Clinical and Experimental Immunology·S NomuraH Nagata

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