Abstract
71 patients with systemic lupus erythematosus (SLE) were studied for the occurrence of platelet antibodies by immunoblotting. Binding of IgG antibodies to platelet protein antigens was observed in 39 of the 71 patients. The most frequently detected and exceptionally strongly reacting antibodies were directed against platelet protein antigens with an approximate molecular weight of 65 kDa under nonreducing conditions. These antibodies were autoreactive and, when followed, they usually persisted. Interestingly, in this group of well-defined SLE patients, platelet antibodies against the most common targets (65 kDa) were significantly associated with the lupus anticoagulant, a history of thrombocytopenia and thrombosis, particularly with arterial occlusions. The lupus anticoagulant, on the other hand, correlated significantly only with venous thrombosis. In addition to the lupus anticoagulant, platelet antibodies against this unknown platelet protein may thus be a marker of a higher risk of thrombosis in SLE patients.
References
Jul 1, 1988·European Journal of Haematology·M GalliT Barbui
Sep 1, 1987·British Journal of Haematology·C KaplanJ P Cartron
Nov 1, 1986·Tissue Antigens·J H HermanP M Ness
Jul 1, 1985·American Journal of Hematology·D A GastineauE J Bowie
Jan 31, 1981·Lancet·L O CarrerasA Van Assche
Oct 8, 1983·British Medical Journal·M L BoeyG R Hughes
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Jan 1, 1981·Journal of Immunological Methods·J MulshineJ D Clough
Feb 1, 1980·Annals of Internal Medicine·J R MuehS I Rapaport
Citations
Jan 1, 1992·British Journal of Haematology·U Nieminen, R Kekomäki
Dec 1, 1993·British Journal of Haematology·Y KurataY Matsuzawa
Jan 1, 1997·Lupus·D G WahlG Thibaut
Mar 1, 1992·Transfusion Medicine·R KekomäkiP Kero
Feb 1, 1993·British Journal of Haematology·R KekomäkiM Laes
Oct 1, 1994·European Journal of Haematology·F FabrisA Girolami
Apr 1, 1996·European Journal of Haematology·L ArforsA K Lefvert
Jul 10, 2001·American Journal of Hematology·H Takahashi, M Moroi
Jan 1, 1996·Annual Review of Medicine·S S Shapiro
May 5, 1999·European Journal of Haematology·S KoskelaR Kekomäki
Aug 8, 2012·Nature Reviews. Rheumatology·Eric BoilardPeter A Nigrovic
Oct 1, 1996·Lupus·D A Triplett
Dec 1, 1994·British Journal of Haematology·G RockN N Tandon
Sep 1, 1994·Baillière's Clinical Haematology·L A Harker, S R Hanson