Platelet calmodulin levels in adolescent idiopathic scoliosis: do the levels correlate with curve progression and severity?

Spine
Thomas LoweMichael O'Brien

Abstract

This ongoing longitudinal study evaluates simultaneous radiographic and platelet calmodulin determinations for patients with idiopathic scoliosis who are skeletally immature. To determine whether platelet calmodulin levels correlate with curve progression and severity. A previous study based on a single calmodulin determination and a single radiograph identified higher calmodulin levels in progressive curves and in higher magnitude curves. A longitudinal study was needed to demonstrate the relation of calmodulin to curve changes for individual patients over time during the growth period. In this study, 55 patients with idiopathic scoliosis of varying types and severity were followed longitudinally with serial radiographs and platelet calmodulin determinations. A Risser sign was recorded for each radiograph at each visit. Calmodulin levels increased in all the patients with progressive curves (13/13), remained stable in 73% of the patients with nonprogressive curves (11/15), and were higher generally in curves greater than 30 degrees and double structural curves. Calmodulin levels usually decreased in patients undergoing brace treatment (14/17) or spine fusion (9/10). It appears that platelet calmodulin levels correlate closely ...Continue Reading

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Citations

Mar 10, 2012·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Emre AcarogluAlain Moreau
Dec 19, 2008·Spine·Jan-Willem M Kouwenhoven, René M Castelein
Jul 5, 2008·Journal of Spinal Disorders & Techniques·Kevin L McIntireWen Liu
Jan 1, 2012·Scientifica·Philip F Giampietro
Apr 8, 2009·Trends in Endocrinology and Metabolism : TEM·Dominique LeboeufFlorina Moldovan
May 6, 2008·Lancet·Stuart L WeinsteinJose A Morcuende
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Mar 25, 2015·The Spine Journal : Official Journal of the North American Spine Society·Ning XieFeng Tang
Dec 10, 2016·Scoliosis and Spinal Disorders·A GrauersP Gerdhem
Feb 6, 2018·The Open Orthopaedics Journal·Maja Fadzan, Josette Bettany-Saltikov
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Aug 14, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Zhuo-Tao LiangHong-Qi Zhang

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