Platelet-camouflaged nanococktail: Simultaneous inhibition of drug-resistant tumor growth and metastasis via a cancer cells and tumor vasculature dual-targeting strategy

Theranostics
Lijia JingYang Wang

Abstract

Multidrug resistance (MDR) poses a great challenge to cancer therapy. It is difficult to inhibit the growth of MDR cancer due to its chemoresistance. Furthermore, MDR cancers are more likely to metastasize, causing a high mortality among cancer patients. In this study, a nanomedicine RGD-NPVs@MNPs/DOX was developed by encapsulating melanin nanoparticles (MNPs) and doxorubicin (DOX) inside RGD peptide (c(RGDyC))-modified nanoscale platelet vesicles (RGD-NPVs) to efficiently inhibit the growth and metastasis of drug-resistant tumors via a cancer cells and tumor vasculature dual-targeting strategy. Methods: The in vitro immune evasion potential and the targeting performance of RGD-NPVs@MNPs/DOX were examined using RAW264.7, HUVECs, MDA-MB-231 and MDA-MB-231/ADR cells lines. We also evaluated the pharmacokinetic behavior and the in vivo therapeutic performance of RGD-NPVs@MNPs/DOX using a MDA-MB-231/ADR tumor-bearing nude mouse model. Results: By taking advantage of the self-recognizing property of the platelet membrane and the conjugated RGD peptides, RGD-NPVs@MNPs/DOX was found to evade immune clearance and target the αvβ3 integrin on tumor vasculature and resistant breast tumor cells. Under irradiation with a NIR laser, RGD-NPVs...Continue Reading

Citations

Dec 21, 2019·Journal of Receptor and Signal Transduction Research·Yang YangZhiyun Wang
Feb 27, 2020·Nanomedicine·Shuaijun ZouLiming Zhang
Aug 3, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhenhua LiKe Cheng
Dec 19, 2019·Frontiers in Bioengineering and Biotechnology·Nan ZhangQiang Ma
Mar 3, 2020·Frontiers in Pharmacology·Shengxian LiYinghao Sun
Nov 23, 2019·Journal of Receptor and Signal Transduction Research·Guanqun Ma, Yingwu Liu
Mar 12, 2020·Frontiers in Bioengineering and Biotechnology·Min Woo KimYong Il Park
Apr 15, 2019·Environmental Science and Pollution Research International·Shaimaa MaherHaitham Kalil
Nov 24, 2020·Chemical Society Reviews·Guo-Feng LuoXian-Zheng Zhang
Dec 20, 2020·International Journal of Molecular Sciences·Melania DovizioPaola Patrignani
Nov 21, 2020·Nanomaterials·Alexandra Mavridi-PrinteziMarco Montalti
Nov 22, 2020·Biology·Carla Jiménez-JiménezMaría Vallet-Regí
Feb 27, 2021·Clinical and Translational Medicine·Minghai ZhangYu Wang
Apr 3, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xiaoyan GuNianping Feng
Apr 17, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Ya-Xuan ZhuFu-Gen Wu
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Jun 15, 2021·Chemical Science·Kaiye WangBo Tang
Aug 31, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Elham SeyyedniaHadi Valizadeh

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Methods Mentioned

BETA
protein assay
fluorescence spectroscopy
fluorescence imaging
irradiating
PCR
transmission electron microscopy
electrophoresis

Software Mentioned

Origin

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