Platelet changes after a saturated fat meal and their prevention by Dazmegrel, a thromboxane synthetase inhibitor

J J BelchC D Forbes


A saturated fat meal was given to 10 normal males both before and after pretreatment with UK38,485, a thromboxane synthetase inhibitor (Dazmegrel, Pfizer Central Research, Sandwich, Kent, United Kingdom). Following the fat meal at 2 and 4 hr there was laboratory evidence of platelet activation. Dazmegrel lowered baseline platelet activity and lessened platelet activation following the fat meal. This drug should be investigated further as a potential antithrombotic agent.


May 26, 1973·Lancet·G HornstraA J Vergroesen
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Jan 1, 1982·International Archives of Allergy and Applied Immunology·G P SandilandsC J Lewis
Jan 1, 1983·British Journal of Clinical Pharmacology·H M Tyler
Jul 15, 1982·Thrombosis Research·R V JohnstonC R Prentice
Jul 1, 1959·The Journal of Clinical Investigation·N ALKJAERSIGS SHERRY

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Dec 1, 1992·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S BisovskyH Sinzinger
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