Platelet chemokines in vascular disease.

Arteriosclerosis, Thrombosis, and Vascular Biology
Christian A GleissnerKlaus Ley

Abstract

Platelets are a rich source of different chemokines and express chemokine receptors. CXCL4 is highly abundant in platelets and involved in promoting monocyte arrest from rolling and monocyte differentiation to macrophages. CXCL4 can also associate with CCL5 and amplify its effect on monocytes. The megakaryocyte CXCL7 gene product is proteolytically cleaved into the strong neutrophil chemoattractant, NAP-2, which has also been implicated in repair cell homing to vascular lesions. Platelet adhesion can induce release of CCL2 and CXCL8 from endothelial cells. Conversely, the chemokines CCL17, CCL22, and CXCL12 made by other cells amplify platelet activation. Platelet chemokines enhance recruitment of various hematopoietic cells to the vascular wall, fostering processes such as neointima formation, atherosclerosis, and thrombosis, but also vessel repair and regeneration after vascular injury.

References

Jan 1, 1976·Annals of the New York Academy of Sciences·L A HarkerJ Glomset
Aug 1, 1992·The Journal of Experimental Medicine·Y KameyoshiJ M Schröder
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·T F DeuelE T Kaiser
Jun 1, 1993·Biologicals : Journal of the International Association of Biological Standardization·K J Lambert
Jan 1, 1997·Advances in Experimental Medicine and Biology·H D FladE Brandt
Oct 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·W A KuzielN Maeda
Mar 26, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·I M HayesR J Williams
Mar 17, 1999·The Journal of Clinical Investigation·J GoslingI F Charo
Apr 23, 1999·The Journal of Biological Chemistry·F PetersenD Spillmann
Nov 5, 1999·Nature Medicine·E LutgensR A Flavell
Jun 3, 2000·Annual Review of Immunology·D Rossi, A Zlotnik
Jan 4, 2001·Immunological Reviews·E BrandtH D Flad
Feb 24, 2001·Bratislavské lekárske listy·M Buc, M Bucova
Mar 15, 2001·Thrombosis Research·S Abi-YounesA D Luster
Jul 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jens FleischerFrank Petersen
Dec 6, 2002·The Journal of Biological Chemistry·Taher NassarAbd Al-Roof Higazi
Jul 10, 2003·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Adrian R L Gear, David Camerini
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·J E Italiano, R A Shivdasani
Dec 4, 2003·Thrombosis and Haemostasis·Stephanie PitsilosBruce S Sachais
Jan 15, 2004·Trends in Cardiovascular Medicine·Yuqing Huo, Klaus F Ley
Jul 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Olga PervushinaFrank Petersen
Aug 21, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ingo FrickeSven Brandau

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Citations

Apr 29, 2010·Current Atherosclerosis Reports·Anders Mälarstig, Anders Hamsten
Mar 4, 2011·Current Atherosclerosis Reports·S SivapalaratnamG M Dallinga-Thie
Jul 28, 2013·Immunobiology·Ioana Madalina Fenyo, Anca Violeta Gafencu
Mar 7, 2013·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Yutaka NaguraKoki Takahashi
May 6, 2011·The New England Journal of Medicine·Julian Ilcheff BorissoffHugo ten Cate
Apr 12, 2011·Thrombosis and Haemostasis·Alan T Nurden
Nov 17, 2009·Circulation Research·Christian A GleissnerKlaus Ley
Apr 14, 2012·Circulation Research·Daniel I Simon, David Zidar
Dec 14, 2011·Hematology·Zane S Kaplan, Shaun P Jackson
Feb 5, 2010·Journal of Neuroinflammation·Lawrence L HorstmanAlireza Minagar
Feb 12, 2014·PLoS Neglected Tropical Diseases·Elisabeth AstrupGeorge M Varghese
Apr 4, 2014·Cancer Metastasis Reviews·David G MenterKenneth V Honn
Nov 10, 2013·Future Microbiology·Cornelia SpethGünter Rambach
Dec 4, 2013·Tissue Engineering. Part a·Bo HanCharisse Tayag
Jul 24, 2010·Mediators of Inflammation·Giovanni AnfossiMariella Trovati
Jul 16, 2014·Proceedings of the National Academy of Sciences of the United States of America·Myriam LabelleRichard O Hynes
Apr 8, 2014·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Brian E CrucianScott M Smith
Oct 16, 2015·Tissue Engineering. Part C, Methods·Jagoda M JalowiecMarietta Herrmann
Oct 23, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Lauren A BiwerTaben M Hale
Sep 12, 2014·Thrombosis and Haemostasis·Daniel DuerschmiedIngo Ahrens
Dec 18, 2013·Hämostaseologie·D WolfA Zirlik
Oct 17, 2015·Nature Reviews. Immunology·Dietmar Vestweber
Mar 26, 2015·Platelets·Archie McNicol
Mar 4, 2015·Platelets·Steven W Kerrigan
Feb 26, 2015·Cardiovascular Research·Jan Rossaint, Alexander Zarbock
Oct 15, 2014·Dental Materials Journal·Mohammed A AlfarsiSaso Ivanovski
Jun 20, 2015·Mediators of Inflammation·Katsuhiko NaruseHiroshi Kobayashi
Jun 11, 2016·Critical Reviews in Clinical Laboratory Sciences·Xiaohong Ruby XuHeyu Ni
Dec 9, 2016·Platelets·Oliver PagelRené P Zahedi
Oct 7, 2014·Cellular Signalling·Tony G WalshAlastair W Poole
Feb 9, 2017·Blood·Melinda D WuJonathan R Lindner

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