Platelet concentrates modulate myeloid dendritic cell immune responses

Platelets
Katrina K KiMelinda M Dean

Abstract

Platelet transfusion has been reported to modulate the recipients' immune system. To date, the precise mechanism(s) driving poor patient outcomes (e.g., increased rate of mortality, morbidity, infectious complications and prolonged hospital stays) following platelet transfusion are largely undefined. To determine the potential for platelet concentrates (PC) to modulate responses of crucial immune regulatory cells, a human in vitro whole blood model of transfusion was established. Maturation and activation of human myeloid dendritic cells (mDC) and the specialized subset blood DC antigen (BDCA)3+ DC were assessed following exposure to buffy-coat derived PC at day (D)2 (fresh) and D5 (date-of-expiry). In parallel, to model recipients with underlying viral or bacterial infection, polyinosinic:polycytidylic acid or lipopolysaccharide was added. Exposure to PC had less of an impact on mDC responses than BDCA3+ DC responses. PC alone downregulated BDCA3+ DC expression of co-stimulatory molecules CD40 and CD80. In the model of viral infection, PC downregulated expression of CD83, and in the bacterial model of infection, PC downregulated CD80, CD83, and CD86. PC alone suppressed mDC production of interleukin (IL)-8, IL-12 and tumor nec...Continue Reading

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Citations

Mar 15, 2018·Platelets·Roshan Noor MohamedYousef Al-Thomali
Mar 23, 2018·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Katrina K KiMelinda M Dean
Jul 10, 2020·The Kaohsiung Journal of Medical Sciences·Lin-Qiang TianWen-Jie Ren
Jul 15, 2020·Journal of Leukocyte Biology·Meera V SinghSanjay B Maggirwar
Jun 28, 2019·Frontiers in Immunology·Lucas Secchim RibeiroBernardo S Franklin

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