Platelet count as a new biomarker for acute kidney injury induced by hemorrhagic shock

Platelets
Ming WuYong-Wen Feng

Abstract

The aim of this study was to investigate the association between nadir platelet count and acute kidney injury (AKI) or 28-day all-cause mortality induced by hemorrhagic shock (HS), and to determine the cutoff value of nadir platelet count in HS clinical practice. This retrospective study included hospitalized patients enrolled in a tertiary-care teaching hospital from January 1, 2010 to December 31, 2015. Clinical data from HS admitted to the intensive care unit (ICU) were evaluated. Nadir platelet count was defined as the lowest values in the first 48 h. Multivariate logistic regression and Cox proportional hazards regression were used to assess the correlation between nadir platelet count and AKI or 28-day all-cause mortality induced by HS, respectively; the area under receiver operating characteristic (AU-ROC) and Youde's index were used to determine the optimal cutoff value of nadir platelet count. Kaplan-Meier's method and log-rank test were assessed for the 28-day all-cause mortality in AKI and non-AKI groups. Of 1589 patients screened, 84 patients (mean age,37.1 years; 58 males) were included in the primary analysis in which 30 patients with AKI. Multiple logistic results indicated that nadir platelet count was a risk fa...Continue Reading

References

Jul 1, 1985·Scandinavian Journal of Haematology·B J Bain
Jun 21, 2002·The New England Journal of Medicine·Abderrezak Bouchama, James P Knochel
Oct 6, 2009·Journal of the American College of Surgeons·Shahid ShafiJohn J Fildes
Dec 28, 2010·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Arnaud Van LindenThomas Walther
Mar 26, 2011·Nature Reviews. Immunology·John W SempleJohn Freedman
Nov 25, 2011·Kidney International·Steven G CocaChirag R Parikh
Aug 30, 2012·Transfusion·Simon J StanworthUNKNOWN Intensive Care Study of Coagulopathy Investigators
Jul 5, 2013·American Journal of Physiology. Renal Physiology·Naushad A JungleeJamie H Macdonald
Nov 26, 2013·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Muhammad Zaman Khan AssirJaved Akram
Mar 4, 2014·Blood·Craig N MorrellKristina L Modjeski
Mar 29, 2014·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Hasan JilaihawiRaj R Makkar
Oct 16, 2014·Kidney International·Mark E ThomasMarlies Ostermann
Jan 16, 2015·Seminars in Thrombosis and Hemostasis·Marco Ranucci
Mar 26, 2015·Platelets·Craig N Jenne, Paul Kubes
Jul 2, 2015·The Journal of Trauma and Acute Care Surgery·Joel EltermanMartin Schreiber
Jul 15, 2015·Experimental and Therapeutic Medicine·Shu ChenPaerhati Baiheti
Aug 27, 2015·The Journal of Trauma and Acute Care Surgery·Mikael ErikssonAnders Oldner
Sep 6, 2015·Clinical Journal of the American Society of Nephrology : CJASN·John P ReillyMichael G S Shashaty
Apr 1, 2012·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·J M FeeneyL M Jacobs
Dec 23, 2016·British Journal of Haematology·Lise J EstcourtUNKNOWN British Committee for Standards in Haematology
Jan 5, 2017·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·D DammersE Ter Avest
Oct 17, 2017·Current Opinion in Critical Care·Anatole HarroisJacques Duranteau
Nov 13, 2017·Journal of Cardiothoracic and Vascular Anesthesia·Chang-Hoon KooJae-Hyon Bahk
Jan 25, 2018·The New England Journal of Medicine·Jeremy W Cannon
May 16, 2018·Nature Reviews. Nephrology·Marcel P B JansenJoris J T H Roelofs
Oct 27, 2018·Military Medical Research·Florian BöschIrshad H Chaudry

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