PMID: 22338571Feb 18, 2012Paper

Platelet-derived chemokines in atherogenesis: what's new?

Current Vascular Pharmacology
Christian A Gleissner

Abstract

Over the past decade, platelets have been demonstrated to have various functions beyond their role in hemostasis. Platelets possess a rich repertoire of chemokines that are stored in their alpha granules and can be released upon activation. The pro-atherogenic effects of activated platelets are most likely mediated by release of these pro-inflammatory mediators that promote recruitment, activation or differentiation of other cell types including endothelial cells and leukocytes. These effects have been excellently reviewed in the past by various authors. The current review will therefore focus on novel findings. A specific focus will be put on CXCL4, on which a lot of new data have been published since 2008. Thus, the effects of CXCL4 on macrophage differentiation have been studied in detail revealing that CXCL4 induces a specific macrophage phenotype. Furthermore, novel data on CXCL4L1, a protein similar to CXCL4 that is probably transcribed from a duplication of the PF4 gene coding for CXCL4, will be discussed. A very interesting study has recently demonstrated that the inhibition of heterophilic chemokine interactions using a specifically designed small molecule can inhibit atherogenesis in Apoe-/- mice, thereby demonstratin...Continue Reading

Citations

Jun 21, 2013·Thrombosis and Haemostasis·E KarshovskaP von Hundelshausen
Aug 26, 2014·Frontiers in Physiology·Philipp von Hundelshausen, Martin M N Schmitt
Jun 11, 2016·Critical Reviews in Clinical Laboratory Sciences·Xiaohong Ruby XuHeyu Ni
Oct 25, 2012·American Journal of Men's Health·Ken TillmanKristin Whitty
Jul 19, 2017·Frontiers in Immunology·Juliana Araújo de Carvalho SchettiniLeuridan Cavalcante Torres
Jul 7, 2017·Journal of Clinical Periodontology·Mathieu Brousseau-NaultHugh Kim
Jun 11, 2021·Clinical and Experimental Immunology·Yanfang ZhaoYuekang Xu

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