PMID: 11345198May 10, 2001Paper

Platelet-derived growth factor enhances granulopoiesis via bone marrow stromal cells

International Journal of Hematology
M YangB H Chong

Abstract

Platelet-derived growth factor (PDGF), a growth factor for connective tissue cells, stimulates erythropoiesis and megakaryocytopoiesis in vitro but the effect of PDGF on granulocyte proliferation remains unknown. The effect of the recombinant human PDGF-BB isoform on granulopoiesis was investigated in this study. The results show that PDGF significantly stimulated murine colony-forming unit-granulocyte-monocyte (CFU-GM) proliferation in a dose-dependent manner (1 to 100 ng/mL) using murine bone marrow cells (n = 4). Maximum stimulation was obtained with 50 ng/mL of PDGF (P < .01). The effect of PDGF on murine CFU-GM proliferation was compared with that of interleukin (IL)-3, IL-6, granulocyte-monocyte colony-stimulating factor (GM-CSF), and acidic fibroblast growth factor (aFGF) at their optimal doses. The stimulating activity of PDGF was higher than that of aFGF but lower than that of IL-3, IL-6, or GM-CSF. There is no synergistic effect between PDGF and IL-3 or IL-6, but a significant enhancing effect was observed in IL-3 plus IL-6. PDGF also stimulated the growth of CFU-GM with CFU-megakaryocyte in the presence of bone marrow stromal cells. We also found that PDGF had similar a effect on human CFU-GM proliferation using bone...Continue Reading

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Citations

Feb 16, 2002·Journal of Hematotherapy & Stem Cell Research·Emanuela MoroniMarco Presta
Dec 29, 2004·Leukemia & Lymphoma·Ikuo Kashiwakura, Tsuneo A Takahashi
Nov 23, 2006·Mechanisms of Ageing and Development·Joyce S G Yeoh, Gerald de Haan

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