Platelet-derived growth factor promotes endometrial epithelial cell proliferation

American Journal of Obstetrics and Gynecology
L MunsonS Van Meter

Abstract

Our purpose was to determine the effects of platelet-derived growth factor on the proliferation of endometrial epithelial cells. Platelet-derived growth factor and its receptors have been identified in the endometrium, and platelet-derived growth factor is a mitogen for endometrial stromal cells. Released from macrophages and platelets at sites of ectopic endometrial growth, platelet-derived growth factor could promote the progression of endometriosis and endometrial cancer. Endometrial epithelial cell lines were developed from proliferative-phase endometria from two patients without endometrial lesions. Cell lines were confirmed to be epithelial. Proliferation assays were conducted on both lines with recombinant human platelet-derived growth factor-AA, AB, and BB. Assays were also performed at different doses, times, and cell densities with platelet-derived growth factor. All isoforms of platelet-derived growth factor were potent mitogens for both endometrial epithelial cell lines. The greatest proliferative responses were achieved at 10 ng/ml and at 24 hours. Responses decreased significantly in confluent cultures. These results suggest that endometrial epithelial cells have functional platelet-derived growth factor-alpha rec...Continue Reading

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Citations

Apr 13, 2002·Annals of the New York Academy of Sciences·Robert N TaylorMichael D Mueller
May 13, 2008·Animal Reproduction Science·Christine HoffmannHeinz-Adolf Schoon
Oct 24, 2007·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Francesca MiniciRosanna Apa
Oct 20, 2017·Yonsei Medical Journal·Hang Yong JangHyuntae Park
Mar 10, 2005·The Journal of Clinical Endocrinology and Metabolism·Harunobu MatsumotoIsao Miyakawa

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