Platelet-Derived Microparticles: A New Index of Monitoring Platelet Activation and Inflammation in Kawasaki Disease

Indian Journal of Pediatrics
Jing JinHaiguo Yu

Abstract

To investigate the dynamic changes of platelet-derived microparticles (PDMP) in Kawasaki disease (KD) and its clinical significance and to study its relationship with intravenous immunoglobulin (IVIG) resistance, inflammatory indicators and aspirin treatment in children with KD. Twenty children with KD were enrolled as the experimental group, while 20 age- and gender-matched children with common febrile disease were included in the control group. Blood samples were drawn before and 7-10 d after IVIG infusion and thereafter at 1, 2, and 3 mo after the onset of KD to estimate the PDMP concentrations by enzyme linked immunosorbent assay (ELISA). C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR), procalcitonin (PCT), and cytokines [Interleukin-6 (IL-6), Tumor necrosis factor-α (TNF-α), and Soluble interleukin-2 (sIL-2R)] were also measured. The level of PDMP in KD children before IVIG was significantly higher than that in controls (P < 0.0001). The PDMP level in KD children decreased significantly at 7 to 10 d after IVIG (P < 0.0001) and then decreased to the lowest level in the course of 1 to 2 mo. Some children's PDMP level rebounded in the course of 3 mo (P = 0.047). In addition, the mean level of PDMP in IVIG-re...Continue Reading

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Citations

Feb 12, 2019·Indian Journal of Pediatrics·Pandiarajan Vignesh, Surjit Singh
Jul 6, 2019·Frontiers in Pediatrics·Himanshi ChaudharySurjit Singh
Feb 3, 2021·European Journal of Pediatrics·Jae Hui Park, Hee Joung Choi
May 6, 2021·Free Radical Biology & Medicine·Nan YangMing-Lin Liu
Mar 18, 2020·Genes & Diseases·Kanika AroraSurjit Singh

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