Platelet-derived Wnt antagonist Dickkopf-1 is implicated in ICAM-1/VCAM-1-mediated neutrophilic acute lung inflammation.

Blood
Yujie GuoLin Liu

Abstract

Neutrophil infiltration represents the early acute inflammatory response in acute lung injury. The recruitment of neutrophils from the peripheral blood across the endothelial-epithelial barrier into the alveolar airspace is highly regulated by the adhesion molecules on alveolar epithelial cells (AECs). Wnt/β-catenin signaling is involved in the progression of inflammatory lung diseases including asthma, emphysema, and pulmonary fibrosis. However, the function of Wnt/β-catenin signaling in acute lung inflammation is unknown. Here, we identified platelet-derived Dickkopf-1 (Dkk1) as the major Wnt antagonist contributing to the suppression of Wnt/β-catenin signaling in AECs during acute lung inflammation. Intratracheal administration of Wnt3a or an antibody capable of neutralizing Dkk1 inhibited neutrophil influx into the alveolar airspace of injured lungs. Activation of Wnt/β-catenin signaling in AECs attenuated intercellular adhesion molecule 1 (ICAM-1)/vascular cell adhesion molecule 1 (VCAM-1)-mediated adhesion of both macrophages and neutrophils to AECs. Our results suggest a role for Wnt/β-catenin signaling in modulating the inflammatory response, and a functional communication between platelets and AECs during acute lung in...Continue Reading

References

Apr 1, 1997·American Journal of Respiratory and Critical Care Medicine·J F PittetM A Matthay
Dec 22, 1999·The Journal of Immunology : Official Journal of the American Association of Immunologists·S RosseauJ Lohmeyer
Dec 1, 2001·American Journal of Respiratory Cell and Molecular Biology·B Beck-SchimmerP A Ward
Jul 11, 2002·The European Respiratory Journal·B Beck-SchimmerR C Schimmer
Apr 23, 2003·The American Journal of Pathology·Marco ChilosiClaudio Doglioni
Aug 12, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Anna E BortnickSandra R Bates
Oct 4, 2003·Nature Reviews. Drug Discovery·Shaun P Jackson, Simone M Schoenwaelder
Apr 13, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jiwang ChenLin Liu
Aug 3, 2004·Nature Reviews. Drug Discovery·David GustafssonAnn-Catrine Teger-Nilsson
Mar 26, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jun SunJames L Madara
Apr 20, 2005·Cancer Letters·Julien MazieresDavid M Jablons
Aug 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·William A AltemeierW Conrad Liles
Nov 8, 2005·American Journal of Respiratory Cell and Molecular Biology·Ivor S DouglasNorbert F Voelkel
Jul 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susanne HeroldJuergen Lohmeyer
Dec 5, 2006·The Journal of Clinical Investigation·Alexander ZarbockKlaus Ley
Jan 24, 2007·Nature Medicine·Danielle DiarraGeorg Schett
Jul 21, 2007·Free Radical Biology & Medicine·Zhongming ChenLin Liu
Aug 30, 2008·American Journal of Respiratory Cell and Molecular Biology·Fernando A BozzaGuy A Zimmerman
Oct 28, 2008·Experimental Hematology·Sachin Malhotra, Paul W Kincade
Mar 11, 2009·Frontiers in Bioscience (Landmark Edition)·Alexander Zarbock, Klaus Ley
Jun 19, 2009·Nature Reviews. Molecular Cell Biology·Stephane Angers, Randall T Moon
Nov 21, 2009·American Journal of Respiratory and Critical Care Medicine·Sunita SharmaScott T Weiss
Apr 7, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Lynn M Crosby, Christopher M Waters
May 27, 2010·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·K B C ApparaoPhilip L Sannes
Jun 19, 2010·Journal of Applied Physiology·Kristin N KornerupClive P Page
Jul 3, 2010·The American Journal of Pathology·Robert ForonjyJeanine D'Armiento
Jul 24, 2010·The European Respiratory Journal·E-M PfaffM Königshoff
Jul 30, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jan NeumannNorbert Reiling
Sep 23, 2010·Annals of the Rheumatic Diseases·Gisela Ruiz HeilandJochen Zwerina
Nov 4, 2010·Molecular Medicine·Jochen Grommes, Oliver Soehnlein
Jan 27, 2011·Journal of Cell Science·Amarjit MishraLin Liu
Apr 13, 2011·PloS One·Arie J HoogendijkCatharina W Wieland
Jun 15, 2011·Atherosclerosis·Thomas Seifert-HeldMaria K Storch
Jun 28, 2011·Immunopharmacology and Immunotoxicology·Haeyong LeeYoosik Yoon
Sep 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Rachel L ZemansGregory P Downey
Oct 12, 2011·The Journal of Clinical Investigation·Thomas VolckaertStijn P De Langhe
Jan 17, 2012·American Journal of Respiratory and Critical Care Medicine·Jochen GrommesOliver Soehnlein

❮ Previous
Next ❯

Citations

Feb 9, 2016·Expert Review of Hematology·Sofiane TariketFabrice Cognasse
Jun 11, 2016·Transfusion Medicine Reviews·Martha Sola-Visner, Rachel S Bercovitz
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jian-Qin LiLi-Juan Cao
Sep 18, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Nagla A El-SherbeenyHayam Ateyya
Oct 9, 2016·Molecular and Cellular Pediatrics·Chiharu OtaMelanie Königshoff
Nov 8, 2016·Current Opinion in Hematology·Simon PitchfordHeidi C E Welch
Mar 8, 2017·The Journal of Infection·Jan G NelRonald Anderson
Feb 9, 2017·Canadian Journal of Physiology and Pharmacology·Hayam AteyyaNagla A El-Sherbeeny
Sep 6, 2017·Anesthesiology·Colm KeaneJohn G Laffey
Aug 28, 2018·Current Opinion in Hematology·Bo CaiHuisheng Ai
May 17, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Roberta Baetta, Cristina Banfi
Apr 16, 2020·Vox Sanguinis·Bin-Zhen Chen, Rong Xia
Jul 19, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·David K ScovilleTerrance J Kavanagh
Jan 18, 2017·BMC Cell Biology·Xiangming ZengLin Liu
Aug 24, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hendrik BeckertSebastian Reuter
Nov 14, 2018·Scientific Reports·Marta PontremoliCristina Banfi
Oct 15, 2019·Frontiers in Immunology·Jesús Cosin-RogerMª Dolores Barrachina
Sep 30, 2017·American Journal of Respiratory and Critical Care Medicine·Lauralyn A McIntyreUNKNOWN Canadian Critical Care Translational Biology Group
Feb 20, 2018·Experimental and Therapeutic Medicine·Cunxue ZhangXiutai Yuan
Feb 7, 2019·Stem Cells International·Fatemeh SharifpanahHeinrich Sauer
Jan 11, 2020·Frontiers in Immunology·Paula GoesSylvia Thiele
Mar 5, 2020·Cellular and Molecular Life Sciences : CMLS·Jialong YanLinxi Chen
Oct 27, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Wei WangYang Jiao
Jan 30, 2021·The FEBS Journal·Annalise M PsailaKate G R Quinlan
Apr 7, 2020·Cancer Letters·Nikolai JaschkeTilman D Rachner
Jun 22, 2019·Differentiation; Research in Biological Diversity·Wook-Jin Chae, Alfred L M Bothwell
Dec 11, 2021·Journal of Leukocyte Biology·Min Hee ParkWook-Jin Chae

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

American Journal of Respiratory and Critical Care Medicine
Harikrishna TanjoreWilliam E Lawson
The American Journal of Pathology
Edward E Morrisey
© 2021 Meta ULC. All rights reserved