Platelet endothelial cell adhesion molecule-1 and mechanotransduction in vascular endothelial cells

Journal of Internal Medicine
K Fujiwara

Abstract

Endothelial cells are known to respond to mechanical forces such as fluid shear stress and cyclic stretch, but elucidating the mechanism for mechanosensing has been difficult. Experimental data indicate that there are probably several sensing mechanisms. We have recently proposed a novel mechanoresponse mechanism that involves platelet endothelial cell adhesion molecule-1 (PECAM-1). When endothelial cells are stimulated by fluid shear stress, PECAM-1 is tyrosine phosphorylated and activates the extracellular signal-regulated kinase 1 and 2 (ERK1/2) signalling cascade. The same signalling events occurred when we applied pulling force directly on PECAM-1 on the endothelial cell surface using magnetic beads coated with antibodies against the external domain of PECAM-1. These results appear to indicate that PECAM-1 is a mechanotransduction molecule. To our knowledge, this is the first mammalian molecule that is shown to respond to mechanical force directly exerted to it.

References

Nov 1, 1975·Atherosclerosis·J B SilkworthW E Stehbens
Jul 1, 1992·Pflügers Archiv : European journal of physiology·G SchwarzB Nilius
Apr 1, 1990·The Journal of Cell Biology·S M AlbeldaC A Buck
Sep 1, 1988·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·J AndoA Kamiya
May 1, 1985·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·D N KuS Glagov
Sep 13, 1969·Nature·C G CaroR C Schroter
Jan 1, 1995·Cell Motility and the Cytoskeleton·K KatohK Fujiwara
Jul 1, 1995·Physiological Reviews·P F Davies
Apr 1, 1997·Current Opinion in Cell Biology·B G Neel, N K Tonks
Jan 1, 1997·Annual Review of Physiology·B NiliusG Droogmans
Jul 11, 1998·Molecular Biology of the Cell·K KatohK Fujiwara
Aug 7, 1998·The International Journal of Biochemistry & Cell Biology·M Stein-GerlachA Ullrich
Aug 14, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·T NagelM A Gimbrone
Sep 30, 1999·Experimental Cell Research·E DejanaM G Lampugnani
Jul 6, 2000·The American Journal of Pathology·S MahootiJ A Madri
May 2, 2001·The Journal of Cell Biology·K KatohK Fujiwara
Jun 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·L DeMaioD A Antonetti
Oct 3, 2001·Physiological Reviews·B Nilius, G Droogmans
Nov 2, 2002·Circulation Research·John Y-J Shyy, Shu Chien
Apr 12, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Peter J Newman, Debra K Newman
Jun 19, 2004·Endothelium : Journal of Endothelial Cell Research·Yi-Jen ChiuKeigi Fujiwara
Nov 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alan R SchenkelWilliam A Muller

Citations

Jul 8, 2011·Journal of the Royal Society, Interface·Deshun Lu, Ghassan S Kassab
Jun 3, 2011·American Journal of Physiology. Cell Physiology·Peter SobolewskiDavid M Eckmann
Jul 16, 2010·American Journal of Physiology. Cell Physiology·Jing-Xu ZhuH M DeLisser
Apr 11, 2012·International Journal of Vascular Medicine·Hussein M Atta
Nov 12, 2009·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis· Zhixin Li Ming Zhao
Dec 3, 2008·Disease Models & Mechanisms·H Y StevensJohn A Frangos
Apr 13, 2012·PloS One·Manik GoelSanjoy K Bhattacharya
Dec 16, 2006·Endothelium : Journal of Endothelial Cell Research·Gwenaele Garin, Bradford C Berk
Jun 24, 2008·Endothelium : Journal of Endothelial Cell Research·Ken-ichi KusanoKeigi Fujiwara
Dec 14, 2011·Free Radical Biology & Medicine·Peter R Kvietys, D Neil Granger
May 13, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jingyan HanVladimir R Muzykantov
Apr 9, 2008·The Journal of Surgical Research·Kirstie D AndrewsJ A Hunt
Dec 26, 2006·Molecular Immunology·Robert Jan Lebbink, Linde Meyaard
May 31, 2012·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Rainer MittermayrWolfgang Schaden
Jan 30, 2014·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Joseph W WraggRoy Bicknell
Nov 29, 2014·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Peter Sobolewski, Miroslawa El Fray
Aug 5, 2015·Archives of Biochemistry and Biophysics·Alexander N Gasparski, Karen A Beningo
Nov 23, 2011·Biochemical Society Transactions·Stuart Egginton
May 16, 2015·Clinical Science·Sunyoung ParkNader Sheibani
Jul 17, 2015·Biomicrofluidics·M Godoy-GallardoL Hosta-Rigau
May 23, 2016·Current Opinion in Cell Biology·Matthew L Kutys, Christopher S Chen
Jul 16, 2010·Biology of Reproduction·M MerklS Bauersachs
Feb 22, 2017·Biology of the Cell·Sophie SluysmansSandra Citi
May 27, 2017·Integrative Biology : Quantitative Biosciences From Nano to Macro·Daisuke YoshinoMasaaki Sato
Jun 24, 2017·Biology of the Cell·Jessica L SnyderKeigi Fujiwara
Jan 26, 2018·Journal of Cellular Physiology·Anne StrohbachRaila Busch
Sep 18, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Abigail WoodfinSussan Nourshargh
Apr 6, 2006·Journal of Internal Medicine·M Intaglietta, John A Frangos
Sep 5, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Philip M CumminsPaul A Cahill
Jun 15, 2007·American Journal of Physiology. Cell Physiology·Shuji KondoChristine M Sorenson
Apr 12, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Shampa ChatterjeeAron B Fisher
Jul 13, 2016·Shock·Melissa A Kottke, Thomas J Walters
Oct 12, 2010·Cell Adhesion & Migration·H M DeLisser
Feb 23, 2019·Investigative Ophthalmology & Visual Science·Randa S Eshaq, Norman R Harris
Apr 11, 2008·American Journal of Physiology. Renal Physiology·Mark R QuinlanJohn M Fitzpatrick
Jan 31, 2020·Biomaterials·D GholobovaL Thorrez
Dec 22, 2007·Journal of Cell Science·Daniel J MetcalfDaniel F Cutler

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