Platelet endothelial cell adhesion molecule-1 is a major SH-PTP2 binding protein in vascular endothelial cells

FEBS Letters
M MasudaK Fujiwara

Abstract

Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) is rapidly tyrosine phosphorylated in mechanically stimulated vascular endothelial cells (ECs). A 65-kDa protein from ECs specifically bound to the c-Src phosphorylated PECAM-1 cytoplasmic domain and was identified as a protein tyrosine phosphatase SH-PTP2 (SHP2, Syp). PECAM-1 was coimmunoprecipitated by anti-SH-PTP2 from EC extracts as a major binding protein, and the level of association increased when PECAM-1 was tyrosine phosphorylated. This association was mediated by SH2 domains of SH-PTP2. A rapid translocation of SH-PTP2 into cell-cell adhesion sites, where PECAM-1 was localized, occurred in mechanically stimulated cells. Our results suggest that PECAM-1 is a component of a mechanosensing machinery acting upstream of SH-PTP2.

References

Dec 11, 1992·Proceedings of the National Academy of Sciences of the United States of America·R M FreemanB G Neel
Apr 1, 1990·The Journal of Cell Biology·S M AlbeldaC A Buck
Feb 1, 1984·Journal of Biomechanical Engineering·C F Dewey
Feb 17, 1995·The Journal of Biological Chemistry·S PluskeyS E Shoelson
Feb 16, 1995·Nature·T Pawson
Jul 1, 1995·Physiological Reviews·P F Davies
Sep 5, 1995·Biochemical and Biophysical Research Communications·N HaradaK Fujiwara
Mar 12, 1993·Cell·Z SongyangR J Lechleider
Jun 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·Y Xie, W A Muller
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·T T LuJ A Madri

❮ Previous
Next ❯

Citations

Jan 22, 2003·Biochemical and Biophysical Research Communications·Dita GratzingerJoseph A Madri
Oct 2, 2003·Current Opinion in Cell Biology·Neta Ilan, Joseph A Madri
Jan 12, 1999·The Journal of Clinical Investigation·P J Newman
Apr 14, 2011·Journal of Cell Science·Jamie R PrivratskyPeter J Newman
May 10, 2001·Cell Structure and Function·K FujiwaraK Katoh
Oct 27, 2004·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Michitaka MasudaNaoki Mochizuki
Dec 18, 2013·Seminars in Immunopathology·David P Sullivan, William A Muller
Jan 18, 2014·Cell and Tissue Research·Jamie R Privratsky, Peter J Newman
Feb 26, 2014·Cell and Tissue Research·Verena KüppersDietmar Vestweber
Jun 30, 2012·Biomechanics and Modeling in Mechanobiology·Beth L Roman, Kerem Pekkan
Dec 27, 2015·Cellular Signalling·Suowen XuZheng Gen Jin
Jun 15, 2010·Life Sciences·Jamie R PrivratskyPeter J Newman
Mar 6, 2007·Cytokine & Growth Factor Reviews·Verónica E García, H Eduardo Chuluyan
Jul 31, 2007·Journal of Neurochemistry·Jean-Pierre CoutyPierre-Olivier Couraud
Mar 31, 2006·IEEE Transactions on Nanobioscience·Shoogo UenoTakashi Ushida
Apr 6, 2006·Journal of Biochemistry and Molecular Biology·Shigetomo FukuhraNaoki Mochizuki
May 16, 2015·Clinical Science·Sunyoung ParkNader Sheibani
Oct 1, 2005·Leukemia & Lymphoma·Carmen BergomPeter J Newman
May 20, 2015·Cardiovascular Research·William A Muller
Jan 14, 2004·Journal of Atherosclerosis and Thrombosis·Norihiko OhuraJoji Ando
Oct 12, 2010·Cell Adhesion & Migration·Horace M DeLisser
Apr 16, 1998·Experimental Parasitology·M WimmerH W Hofer
Aug 1, 2006·Pathophysiology of Haemostasis and Thrombosis·Suzanne J A Korporaal, Jan-Willem N Akkerman
Jun 24, 2017·Biology of the Cell·Jessica L SnyderKeigi Fujiwara
Jan 23, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·N SheibaniW A Frazier
Apr 12, 2003·FEBS Letters·Denise E Jackson
Dec 20, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Suzanne J A KorporaalJan-Willem N Akkerman
Apr 12, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Peter J Newman, Debra K Newman
Sep 17, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yanping LiuDavid D Gutterman
Feb 25, 2006·The Journal of Biological Chemistry·Jennifer L SalleeKeith Burridge
Apr 12, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Shampa ChatterjeeAron B Fisher
Jun 18, 2004·American Journal of Physiology. Cell Physiology·Christopher D O'BrienHorace M DeLisser

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.