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Platelet factor 4 inhibits FGF2-induced endothelial cell proliferation via the extracellular signal-regulated kinase pathway but not by the phosphatidylinositol 3-kinase pathway

Blood

Oct 18, 2002

Eric SulpiceGerard Tobelem

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PubMed

Abstract

Platelet factor 4 (PF-4) is a member of the chemokine family with powerful antiangiogenic properties. The mechanism by which PF-4 inhibits endothelial cell proliferation is unclear. We investigated the effects of PF-4 on the intracellular signal transduction induced by basic fibroblast ...read more

Mentioned in this Paper

MAP2K1 protein, human
Ovarian Diseases
Chinese Hamster
Biochemical Pathway
FGFR1
Transfection
Adrenal Cortex Diseases
Bioflavonoids
Extracellular
Phosphatidylinositol 3-Kinases
Paper Details
References
  • References37
  • Citations30
1234
  • References37
  • Citations30
123

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Platelet factor 4 inhibits FGF2-induced endothelial cell proliferation via the extracellular signal-regulated kinase pathway but not by the phosphatidylinositol 3-kinase pathway

Blood

Oct 18, 2002

Eric SulpiceGerard Tobelem

PMID: 12384403

DOI: 10.1182/blood.v100.9.3087

Abstract

Platelet factor 4 (PF-4) is a member of the chemokine family with powerful antiangiogenic properties. The mechanism by which PF-4 inhibits endothelial cell proliferation is unclear. We investigated the effects of PF-4 on the intracellular signal transduction induced by basic fibroblast ...read more

Mentioned in this Paper

MAP2K1 protein, human
Ovarian Diseases
Chinese Hamster
Biochemical Pathway
FGFR1
Transfection
Adrenal Cortex Diseases
Bioflavonoids
Extracellular
Phosphatidylinositol 3-Kinases

Feeds With Similar Papers

PI3K/AKT/mTOR Pathway

The PI3K/AKT/mTOR signal transduction pathway is crucial for cell cycle, thus directly regulates cell proliferation, longevity, and cancer. Here is the latest research on this intracellular signaling pathway.

MAPK Pathway

MAPK pathway is a complex signaling pathway that regulates transcription, translation, cell cycle, and proliferation. Targeting this pathway has long been considered a promising strategy for cancer therapy. Here is the latest research on this pathway.

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The Journal of Biological ChemistryJune 23, 1995
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Paper Details
References
  • References37
  • Citations30
1234
  • References37
  • Citations30
123

Download from

Publisher
PubMed
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