Platelet Features and Derivatives in Osteoporosis: A Rational and Systematic Review on the Best Evidence

International Journal of Molecular Sciences
Francesca SalamannaMilena Fini

Abstract

Background: With the increase in aging population, the rising prevalence of osteoporosis (OP) has become an important medical issue. Accumulating evidence showed a close relationship between OP and hematopoiesis and emerging proofs revealed that platelets (PLTs), unique blood elements, rich in growth factors (GFs), play a critical role in bone remodeling. The aim of this review was to evaluate how PLT features, size, volume, bioactive GFs released, existing GFs in PLTs and PLT derivatives change and behave during OP. Methods: A systematic search was carried out in PubMed, Scopus, Web of Science Core Collection and Cochrane Central Register of Controlled Trials databases to identify preclinical and clinical studies in the last 10 years on PLT function/features and growth factor in PLTs and on PLT derivatives during OP. The methodological quality of included studies was assessed by QUIPS tool for assessing risk of bias in the clinical studies and by the SYRCLE tool for assessing risk of bias in animal studies. Results: In the initial search, 2761 studies were obtained, only 47 articles were submitted to complete reading, and 23 articles were selected for the analysis, 13 on PLT function/features and growth factor in PLTs and 10 o...Continue Reading

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Citations

May 31, 2020·International Journal of Molecular Sciences·Maria Valeria CataniValeria Gasperi
Jan 29, 2021·BioMed Research International·Luca FiorilloMarco Cicciù
Feb 17, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Y N DuZ F Zhang
Jul 12, 2021·Trends in Endocrinology and Metabolism : TEM·Francesca SalamannaMilena Fini

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Software Mentioned

Quality in Prognosis Studies ( QUIPS )
ProQuest
Systematic Review Centre for Laboratory Animal Experimentation...
Scopus

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