PMID: 8968180Dec 1, 1996Paper

Platelet function and adrenoceptors during and after induced hypotension using nitroprusside

Anesthesiology
G V DietrichG Hempelmann

Abstract

Hypotension induced by sodium nitroprusside can minimize intraoperative blood loss. The release of endogenous catecholamines can influence adrenoceptors of platelets and thus might change the ability of platelets to aggregate. Forty patients undergoing nasal septum, tympanoplastic, or sphenoid sinus surgery were randomly divided into two groups, those having controlled hypotension (A) and those serving as controls (B). Blood samples were drawn before the operation, after induction of anesthesia, 1 h after the start of the operation, and on the day after surgery. Epinephrine-induced platelet aggregation only increased in the controls on the day after surgery (A: from 49 +/- 25% to 47 +/- 29%; B: from 53 +/- 24% to 72 +/- 14%; mean +/- SD; P < 0.01). Spontaneous platelet aggregation increased in the controls from a median of 1.2 omega/h to 2.4 during the operation and 2.9 on the day after surgery but not after hypotension. On the day after surgery, alpha 2 receptors reached their maximum (A: 238 +/- 164; B: 234 +/- 80 per platelet). During the operation, the norepinephrine concentrations were significantly greater in group A (median, 419 pg/ml) than in group B (median, 217 pg/ml; P < 0.05). Blood loss was greater in the controls ...Continue Reading

References

Nov 1, 1979·The Journal of Clinical Investigation·J S Bennett, G Vilaire
Apr 1, 1989·Anesthesiology·R Hines, P G Barash
Feb 1, 1989·American Journal of Clinical Pathology·R AbbateG F Gensini
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·H S BangaS E Rittenhouse
Jan 1, 1984·Clinical and Laboratory Haematology·J R O'BrienS Davison
Jul 1, 1982·The New England Journal of Medicine·H J Motulsky, P A Insel
Jan 1, 1984·The Journal of Clinical Investigation·A G Gilman
Jan 1, 1982·European Journal of Clinical Pharmacology·O E BroddeK D Bock
Feb 1, 1980·Journal of Pharmacological Methods·D C Cardinal, R J Flower
Nov 1, 1994·Anesthesiology·B A RosenfeldP Goldschmidt

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Citations

Feb 24, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·C S DegouteV Banssillon
Sep 21, 2013·Current Neurology and Neuroscience Reports·Monisha A Kumar
Feb 27, 2004·Journal of Clinical Anesthesia·Stewart J LustikAshwani K Chhibber
Mar 24, 2005·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·M ManolaA Mastella
May 10, 2007·Drugs·Christian-Serge Degoute
Jul 17, 2012·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Umut TuncelNaci Kostakoglu
Jul 20, 2001·AORN Journal·S OzawaT D Ochani

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