Platelet function and bleeding in chronic lymphocytic leukemia and mantle cell lymphoma patients on ibrutinib.

Journal of Thrombosis and Haemostasis : JTH
Elena A DmitrievaVadim V Ptushkin

Abstract

Therapy with irreversible Bruton's tyrosine kinase inhibitor ibrutinib in chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) is associated with bleeding. To propose the predictive markers of such bleeding, as well as mechanisms responsible for decreased bleeding at later therapy stages. We investigate platelet functional activity in 50 CLL and 16 MCL patients on ibrutinib using flow cytometry and light transmission aggregometry. Prior to treatment, both patient groups had decreased platelet counts; impaired aggregation with adenosine diphosphate (ADP); and decreased binding of CD62P, PAC1, and annexin V upon stimulation. Bleeding in patients treated with ibrutinib was observed in 28 (56%) CLL patients, who had decreased aggregation with ADP and platelet count before therapy. Their platelet count on therapy did not change, platelet aggregation with ADP steadily improved, and aggregation with collagen first decreased and then increased in anticorrellation with bleeding. Bleeding in MCL was observed in 10 (62%) patients, who had decreased dense granule release before therapy. ADP and ristocetin induced platelet aggregation in ibrutinib-treated MCL patients increased on therapy, while collagen-induced aggregation evo...Continue Reading

References

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Sep 12, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Alexander P ByeJonathan M Gibbins
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May 1, 2019·Clinical Lymphoma, Myeloma & Leukemia·Marko Lucijanic, Marko Skelin

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Citations

Jan 19, 2021·Journal of Thrombosis and Haemostasis : JTH·Philip Crispin, Elizabeth E Gardiner
Mar 30, 2021·Frontiers in Cell and Developmental Biology·H Yesid EstupiñánC I Edvard Smith
Apr 17, 2021·Hämostaseologie·N A PodoplelovaM A Panteleev
Aug 4, 2021·Current Oncology Reports·Maude SestierDarryl Leong

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