PMID: 22338567Feb 18, 2012Paper

Platelet function and signaling in diabetes mellitus

Current Vascular Pharmacology
Voahanginirina Randriamboavonjy, Ingrid Fleming

Abstract

Diabetes mellitus is associated with the accelerated development of vascular disease and there is evidence that platelets actively contribute to this process. Certainly, platelets are able to modulate the function of endothelial and vascular smooth muscle cells via the direct release of growth factors and pro-inflammatory chemokines but also via the production of microparticles which function as a transcellular delivery system for micro RNAs. This article reviews the intracellular signaling mechanisms underlying the increased activation of diabetic platelets and the involvement of platelets in atherothrombosis development.

Citations

Mar 15, 2014·Cell and Tissue Research·Silvia FischerKlaus T Preissner
Mar 10, 2016·Reviews in Endocrine & Metabolic Disorders·Markolf HanefeldAndreas L Birkenfeld
Mar 10, 2015·The Biochemical Journal·Robert GoggsAlastair W Poole
Jan 10, 2014·Diabetes & Metabolism Journal·Jin Hwa KimSang Yong Kim
Jul 18, 2017·Acta Pharmacologica Sinica·Wei ZhangMing-Lin Liu
Nov 7, 2019·Diabetologia·Naveed AkbarMyriam Aouadi
Nov 7, 2020·International Journal of Molecular Sciences·Anastasia KyselovaVoahanginirina Randriamboavonjy

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