PMID: 590850Nov 1, 1977

Platelet function in fulminant hepatic failure and effect of charcoal haemoperfusion

Gut
M J WestonR Williams

Abstract

In 34 patients with fulminant hepatic failure, platelets, in addition to being reduced in numbers, were smaller than those of healthy controls. In keeping with this, capillary bleeding times were significantly longer than could be accounted for by reduction in numbers alone. In a small group of these patients use of charcoal haemoperfusion for temporary liver support produced a doubling of the capillary bleeding time despite only a small drop in arterial platelet counts. This disproportionate prolongation of bleeding time was almost certainly caused by the loss of larger platelets in the charcoal columns during perfusion, as the mean median volume also fell during perfusion. Rises in screen filtration pressure of blood leaving the columns were found during some perfusions and thought to be indicative of platelet aggregates. Release of vasoactive substances from platelets could account for the hypotension often found at this time.

References

Jan 4, 1975·British Medical Journal·J A ValeR Goulding
Mar 14, 1970·Lancet·M O RakeR Williams
Jul 27, 1972·The New England Journal of Medicine·L A Harker, S J Slichter
Jul 1, 1967·British Journal of Haematology·P M Mannucci, A A Sharp

Citations

Jan 1, 1983·Intensive Care Medicine·M T Weston
Aug 1, 1984·The American Journal of Medicine·S E Lind
Mar 1, 1983·Prostaglandins, Leukotrienes, and Medicine·G DavìA Strano
Mar 12, 1999·The Surgical Clinics of North America·A O ShakilD J Kramer
Oct 30, 1982·Lancet·M J Weston
Oct 30, 1999·Alimentary Pharmacology & Therapeutics·T M Rahman, H J Hodgson
Apr 1, 1981·Intensive Care Medicine·S BraudeR Williams
Jul 1, 1978·Kidney International·J F WinchesterA C Kennedy
Jun 1, 1977·Thrombosis Research·M J WestonR Williams
Aug 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P G LangleyR Williams
Dec 16, 2016·Pediatric Annals·Jonathan CordovaRuba K Azzam
Apr 4, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Esther B BachliEberhard L Renner
Mar 1, 1983·Stroke; a Journal of Cerebral Circulation·S Moncada
Dec 4, 2016·Hematology·Michele P Lambert
Jan 21, 2020·Biomaterials·Maaike K van GelderKarin G F Gerritsen

Related Concepts

Complete Blood Count
Blood Coagulation Disorders
Blood Platelets
Blood Capillaries
Actidose
Hemoperfusion
Liver Dysfunction
Particle Size
Platelet Aggregation

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