PMID: 7123174Jan 1, 1982Paper

Platelet function in rheumatoid arthritis

Scandinavian Journal of Rheumatology
S ColliB Canesi

Abstract

Platelet function tests were evaluated in 20 patients with rheumatoid arthritis (RA), 9 of whom displayed thrombocytosis (greater than 400,000 platelets/microliter). Most patients had an enhanced sensitivity to collagen and epinephrine induced aggregation, as compared with a reference group. In contrast, malondialdehyde (MDA) production, an index of platelet arachidonic acid metabolism, was in the normal range for all the patients except 3, who were LE phenomenon positive. The hypersensitivity of platelets to aggregating stimuli was particularly marked in thrombocytotic patients, who also showed the most striking biochemical and clinical abnormality. These findings indicate the crucial role of platelets in the development and self-sustaining of RA.

References

Jun 1, 1978·Thrombosis Research·S L Pfueller, B G Firkin
Oct 1, 1965·Proceedings of the Society for Experimental Biology and Medicine·H Z MovatT Uriuhara
Jun 1, 1974·The Journal of Clinical Investigation·C M ChesneyR W Colman
Jan 1, 1972·Scandinavian Journal of Rheumatology·O Selroos

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Citations

Apr 15, 2010·Rheumatology International·Armen Yuri GasparyanGeorge D Kitas
Jan 1, 1986·Annals of the Rheumatic Diseases·T J CunninghamK D Muirden
Aug 1, 2014·Seminars in Arthritis and Rheumatism·Jilke BeinsbergerJudith M E M Cosemans
Jul 5, 2007·The Journal of Family Planning and Reproductive Health Care·E Anne MacGregor
Jan 1, 1986·Acta Medica Scandinavica·P OxholmR Manthorpe
Apr 10, 2021·Rheumatology International·Girinivasan ChellamuthuVenus Khanna

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