Platelet hyperactivation, apoptosis and hypercoagulability in patients with acute pulmonary embolism

Thrombosis Research
Samin RezaniaJeffrey A Kline

Abstract

Changes in systemic redox balance can alter platelet activation and aggregation. Acute pulmonary embolism (PE) is a systematic inflammatory disease associated with mechanical shear stress, increased thrombin, catecholamines, serotonin and hemolysis, which cumulatively can hyperactivate platelets and accelerate their turnover. We tested the hypothesis that platelets from patients with moderately severe PE will show hyperstimulation and a pre-apoptotic phenotype associated with microparticles (MPs) in plasma. Blood for platelet respiration and thromboelastography (TEG) was obtained at diagnosis and 24h later from patients (n=76) with image-proven PE, SBP>90mmHg and right ventricular dysfunction demonstrated by echocardiogram or elevated biomarkers. Controls (n=12) were healthy volunteers. At diagnosis, platelets from PE patients had significantly elevated baseline oxygen consumption compared with controls, explained primarily by accelerated electron transport and oxygen wasting with no measurable extramitochondrial oxygen consumption. On thromboelastography, unstimulated thrombin-independent maximum amplitude was increased with PE, 19±14.1 vs.10.5±7.8mm in controls (p=0.002). Compared with controls, platelets from PE patients sho...Continue Reading

Citations

Feb 6, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ruth E McDowellRaed A Dweik
Jul 13, 2018·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Murat GökEnder Ornek
Mar 18, 2020·Pulmonary Circulation·Mads Dam LyhneAsger Andersen
Jan 30, 2021·Blood·Karina AlthausPeter Rosenberger
Jan 12, 2019·Nitric Oxide : Biology and Chemistry·Jeffrey A KlineTim Lahm
May 21, 2021·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Dimpi PatelJawed Fareed

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