Platelet hyperfunction in dogs with malignancies

Journal of Veterinary Internal Medicine
E A McNielM D Salman

Abstract

In vitro platelet aggregometry was performed on whole blood samples from 59 dogs with malignancies and 24 control dogs. Three reagents were used for the aggregation studies: collagen, arachidonic acid, and adenosine diphosphate (ADP). The parameters measured to evaluate response to collagen included delay in the aggregation response, slope of the aggregation curve, maximum aggregation, and adenosine triphosphate (ATP) secretion. The platelets of dogs with malignancies exhibited significantly (P < .05) shorter delays in the aggregation response, higher maximum aggregation, and higher ATP secretion when compared to control dogs. For the weaker reagents, ADP and arachidonic acid, the lowest concentration resulting in aggregation was determined. Platelets of dogs with malignancies tended to aggregate in response to lower concentrations of ADP than did those of controls (P < .05). The response of platelets to the concentrations of arachidonic acid employed in this study was poor, with few samples achieving measurable aggregation. The findings of this study suggest that dogs with malignancies have hyperaggregable platelets.

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Citations

Jun 25, 2009·Veterinary Clinical Pathology·Noel ClanceyEtienne Côté
Feb 22, 2008·Journal of Veterinary Internal Medicine·A T KristensenA L Jensen
Sep 24, 2015·Veterinary Clinical Pathology·Shauna L BloisGabrielle Monteith
Jan 31, 2012·The Veterinary Clinics of North America. Small Animal Practice·Michael O Childress
Jun 1, 2006·Journal of Veterinary Internal Medicine·Douglas J Weiss, Jennifer L Brazzell
Sep 29, 2012·Journal of Veterinary Emergency and Critical Care·Karl E Jandrey
Jul 28, 2016·American Journal of Veterinary Research·Linda J TongRobert E Shiel
Aug 7, 2017·The Veterinary Record·Labrini V AthanasiouXanthi A Rousou
Mar 26, 2003·Veterinary Clinical Pathology·Andreas MoritzDouglas J Weiss
Jan 18, 2019·Journal of Veterinary Emergency and Critical Care·Armelle deLaforcadeElizabeth Rozanski
Mar 11, 2005·American Journal of Veterinary Research·Andreas MoritzDouglas J Weiss
Jan 9, 2008·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Dóra HalmayRóbert Kocsis
Apr 27, 2021·The Journal of Small Animal Practice·A WilkinsonD McClendon

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