Platelet hypersensitivity induced by 1-chloro-2, 4-dinitrobenzene, hydroperoxides and inhibition of lipoxygenase

Thrombosis Research
T D HillG H Rao

Abstract

Platelets administered 1-chloro-2,4-dinitrobenzene to deplete intracellular glutathione (GSH) and inhibit GSH-peroxidase responded with irreversible aggregation to low doses of arachidonic acid (AA) more rapidly than control cells. This increase in sensitivity was correlated to inhibition of GSH-peroxidase, and not with the depletion of GSH. Addition of hydrogen peroxide, 15-hydroperoxyeicosatetraenoic acid, or inhibition of the lipoxygenase metabolic pathway by 4,7,10,13-eicosatetraynoic acid also induced a hypersensitive aggregation response to AA. These results suggest that the three modes of treatment share a common mechanism of increasing AA metabolism to biologically active prostaglandins and thromboxane A2 through alterations in cyclooxygenase kinetics and available enzyme substrate.

References

Dec 29, 1978·Biochemical and Biophysical Research Communications·M E HemlerW E Lands
Apr 1, 1979·Archives of Biochemistry and Biophysics·M E HemlerW E Lands
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·M I SiegelP Cuatrecasas
Aug 28, 1979·Biochemical and Biophysical Research Communications·M I SiegelP Cuatrecasas
Aug 30, 1985·Biochemical and Biophysical Research Communications·G H RaoJ G White
Apr 13, 1982·Biochimica Et Biophysica Acta·G H RaoJ G White
Jan 1, 1981·Progress in Lipid Research·W E Lands

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Citations

Aug 15, 1991·Archives of Biochemistry and Biophysics·T HashizumeT Fujii

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