Platelet levels of dopamine are increased in migraine and cluster headache

Headache
G D'AndreaG Bussone

Abstract

To measure plasma and platelet levels of dopamine in patients with migraine with aura, migraine without aura, and cluster headache. Clinical, genetic, and pharmacological evidences suggest that an abnormality of dopaminergic system plays a role in migraine pathogenesis. Direct evidence of an abnormal metabolism of dopamine in migraine, however, is lacking. Plasma and platelet levels of dopamine were measured in patients with migraine with aura or migraine without aura during headache-free periods and in patients with cluster headache during the remission and active periods, as compared with healthy control subjects, using a multichannel electrochemical high-performance liquid chromatography system. Plasma levels of dopamine were not detectable with our methodology. Platelet levels of dopamine were higher in both types of migraine (migraine without aura = .20 +/- .17 ng/10(8) platelets; migraine with aura = .16 +/- .19 ng/10(8) platelets) than in control subjects (.10 +/- .11 ng/10(8) platelets), although in migraine with aura patients the difference was not significant. Patients with cluster headache showed the highest levels of platelet dopamine (.34 +/- .36 ng/10(8) platelets). Our results support the hypothesis that the dopa...Continue Reading

References

Feb 10, 1977·Nature·J Axelrod, J M Saavedra
Apr 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·G D'AndreaK M Welch
Dec 1, 1990·Cephalalgia : an International Journal of Headache·S Nagel-LeibyE Brown
Sep 1, 1985·British Journal of Clinical Pharmacology·C R JonesJ L Reid
Mar 1, 1987·Cephalalgia : an International Journal of Headache·E Waldenlind, S A Gustafsson
Jun 1, 1981·Cephalalgia : an International Journal of Headache·M Anthony
Jan 1, 1980·Journal of Neural Transmission·E A ParatiE E Müller
Apr 1, 1995·Headache·M Del ZompoM R Pisano
Oct 1, 1993·Cephalalgia : an International Journal of Headache·M Leone, G Bussone
Dec 1, 1995·Cephalalgia : an International Journal of Headache·M G Tozzi-CiancarelliA Carolei
Feb 1, 1996·Cephalalgia : an International Journal of Headache·J CastilloM Noya
Jun 27, 1998·Cephalalgia : an International Journal of Headache·A MasciaJ Schoenen
Aug 5, 1998·Lancet·A MayP J Goadsby
May 19, 2000·Cephalalgia : an International Journal of Headache·P BarbantiR Cerbo
Feb 13, 2001·Cephalalgia : an International Journal of Headache·P BarbantiR Cerbo
Dec 12, 2001·Endocrine Reviews·N Ben-Jonathan, R Hnasko
Mar 8, 2003·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·M MochiP Montagna
Mar 23, 2004·Neuropharmacology·Raffaella GeracitanoNicola B Mercuri
May 26, 2004·Neurology·G D'AndreaG Bussone

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Citations

Jun 11, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·Angelika SchedelPeter Bugert
Jul 16, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·Suneet MehrotraAntoinette MaassenVanDenBrink
Sep 4, 2009·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Giovanni D'AndreaDavide Colavito
May 22, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·G D'Andrea, A Leon
Feb 1, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·T OnayaY Kiuchi
Jun 1, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Giovanni D'AndreaAlberta Leon
May 25, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Piero BarbantiG Egeo
Mar 11, 2009·Current Pain and Headache Reports·Dagny HolleZaza Katsarava
Mar 20, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·E García-MartínF J Jiménez-Jiménez
Aug 5, 2006·Cephalalgia : an International Journal of Headache·G D'AndreaG Bussone
Sep 25, 2007·Cephalalgia : an International Journal of Headache·A M RhodeS Evers
Jul 16, 2008·Cephalalgia : an International Journal of Headache·A PerrottaG Nappi
Jan 28, 2009·Cephalalgia : an International Journal of Headache·R ShuklaR S Yadav
Feb 4, 2009·Cephalalgia : an International Journal of Headache·T R VillaD de Souza Carvalho
Sep 26, 2014·Expert Opinion on Drug Metabolism & Toxicology·János TajtiLászló Vécsei
Dec 19, 2015·Clinical Chemistry and Laboratory Medicine : CCLM·Thamara E OsingaIdo P Kema
Jul 16, 2013·Headache·Paul Durham, Spyros Papapetropoulos
Jun 8, 2012·Headache·Giovanni D'AndreaAlberta Leon
Oct 7, 2009·Headache·Hans-Jürgen GruberMartie Truschnig-Wilders
Mar 4, 2014·Developmental Medicine and Child Neurology·Christophe GoubauKathleen Freson
May 21, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Stefano ZanigniPeter P Pramstaller
May 29, 2015·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·G D'AndreaA Leon
Oct 27, 2016·Neuroscience·Katerina Zorina-LichtenwalterL Diatchenko
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Muhammad Zahid Khan, Waqas Nawaz
Mar 25, 2016·Cephalalgia : an International Journal of Headache·Giovanni D'AndreaAlberta Leon
May 8, 2016·Cephalalgia : an International Journal of Headache·Yao-Jun LiaoSan-Qing Jin
Mar 16, 2013·Cephalalgia : an International Journal of Headache·Giovanni D'AndreaFrancesco Perini
May 28, 2013·Cephalalgia : an International Journal of Headache·Cherubino Di LorenzoFrancesco Pierelli
Dec 1, 2012·Cephalalgia : an International Journal of Headache·Elizabeth LerouxAnne Ducros
Feb 19, 2010·Current Opinion in Neurology·Annabelle R CharbitPeter J Goadsby
Jul 18, 2017·Journal of Human Kinetics·Randy L AldretDavid M Bellar
Sep 1, 2017·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Håkan AshinaSait Ashina
Dec 7, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Jonas SpaakJohn S Floras
May 4, 2011·Arquivos de neuro-psiquiatria·Andréa Regina Correa MoutranDeusvenir de Souza Carvalho
Jul 3, 2017·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Melis Sohtaoğlu SevindikDerya Uludüz
Mar 3, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·G D'AndreaA Leon
May 20, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Zehra Akdag UzunHatice Karaer Unaldi
May 8, 2021·Frontiers in Human Neuroscience·Claudia AltamuraGianluca Coppola
Sep 26, 2021·Eating and Weight Disorders : EWD·Ana Izabela Sobral de Oliveira-SouzaDaniella Araújo de Oliveira

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