Platelet-Like Gold Nanostars for Cancer Therapy: The Ability to Treat Cancer and Evade Immune Reactions

Frontiers in Bioengineering and Biotechnology
Min Woo KimYong Il Park

Abstract

The cell membrane-coating strategy has opened new opportunities for the development of biomimetic and multifunctional drug delivery platforms. Recently, a variety of gold nanoparticles, which can combine with blood cell membranes, have been shown to provide an effective approach for cancer therapy. Meanwhile, this class of hybrid nanostructures can deceive the immunological system to exhibit synergistic therapeutic effects. Here, we synthesized red blood cell (RBC) and platelet membrane-coated gold nanostars containing curcumin (R/P-cGNS) and evaluated whether R/P-cGNS had improved anticancer efficacy. We also validated a controlled release profile under near-infrared irradiation for the ability to target melanoma cells and to have an immunomodulatory effect on macrophages. RBC membrane coating provided self-antigens; therefore, it could evade clearance by macrophages, while platelet membrane coating provided targetability to cancer cells. Additionally, the nutraceutical curcumin provided anticancer and anti-inflammatory effects. In conclusion, the results presented in this study demonstrated that R/P-cGNS can deliver drugs to the target region and enhance anticancer effects while avoiding macrophage phagocytosis. We believe th...Continue Reading

References

Sep 5, 2007·Assay and Drug Development Technologies·Biji T KurienR Hal Scofield
Jun 16, 2009·Nature Materials·Andre E NelMike Thompson
Jul 22, 2010·Angewandte Chemie·Katrin KnopUlrich S Schubert
Jan 25, 2011·Nature Reviews. Cancer·Laurie J Gay, Brunhilde Felding-Habermann
Jun 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Che-Ming J HuLiangfang Zhang
Mar 20, 2012·Blood·Patrick BurgerRobin van Bruggen
Nov 13, 2012·The AAPS Journal·Subash C GuptaBharat B Aggarwal
Apr 5, 2013·Microfluidics and Nanofluidics·Jifu TanYaling Liu
Apr 23, 2013·International Journal of Molecular Sciences·Paul RoachClare Hoskins
Jun 4, 2013·Biological & Pharmaceutical Bulletin·Tatsuhiro Ishida, Hiroshi Kiwada
Oct 23, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tatsuki OkunoTetsuya Kodama
Mar 5, 2014·Seminars in Thrombosis and Hemostasis·Hadi A GoubranThierry Burnouf
Apr 19, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Xuan ZhangJay L Nadeau
Aug 8, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ho Jin KwonByung Cheol Shin
Sep 30, 2015·Advanced Materials·Quanyin HuZhen Gu
Jul 13, 2016·BioMed Research International·Seong-Hoon YunJin-Yeong Han
Dec 8, 2016·Macromolecular Bioscience·Samagya BanskotaAshutosh Chilkoti
Feb 16, 2017·Advanced Materials·Diana DehainiLiangfang Zhang
Mar 11, 2017·International Journal of Nanomedicine·Zhen ZhangXiaoping Qian
Jul 21, 2017·Journal of Traditional and Complementary Medicine·Matthew C FadusHenry T Lynch
Nov 11, 2017·International Journal of Nanomedicine·Haiying HuaYongxing Zhao
Mar 28, 2018·Advanced Materials·Ronnie H FangLiangfang Zhang
Oct 29, 2018·Advances in Experimental Medicine and Biology·Nerymar Ortiz-OteroMichael R King
Dec 7, 2018·International Journal of Molecular Sciences·Min Woo KimAeju Lee
May 16, 2019·Journal of Nanobiotechnology·Haijun WangLi-Min Zhu

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Citations

Jun 11, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yuzhen LiXin Ding
Feb 28, 2021·International Journal of Pharmaceutics·Shalvi Sinai Kunde, Sarika Wairkar
Sep 11, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Pratigyan DashMamoni Dash
May 21, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zahid HussainMohammed A S Abourehab

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Methods Mentioned

BETA
flow cytometry
fluorescence microscopy
ELISA
transmission electron microscopy
confocal microscopy
light microscopy

Software Mentioned

GraphPad
Prism

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