Platelet-lymphocyte conjugation differs between lymphocyte subpopulations

Journal of Thrombosis and Haemostasis : JTH
N LiP Hjemdahl

Abstract

Platelets can bind to, and thereby influence, lymphocyte function. The propensities of different lymphocyte subpopulations to form platelet-lymphocyte conjugates/aggregates (P-Lym) was investigated using four-color whole blood flow cytometry. P-Lym constituted approximately 3% of circulating lymphocytes. Platelet conjugation was most common among large (monocyte-sized) lymphocytes. Platelet activation by ADP slightly increased platelet-T-cell conjugation, mainly to T-cytolytic (Tc) cells, but markedly elevated platelet-natural killer (NK)-cell conjugation. T-cell activation by phytohemagglutinin increased heterotypic conjugation among both T-helper (TH) and Tc cells, whilst NK-cell activation by interleukin-2 affected platelet-NK-cell aggregation little. Neither platelet activation nor lipopolysaccharides-induced B-cell activation enhanced platelet-B-cell aggregation. Activation-dependent heterotypic conjugation was mainly found among large cells, with increased percentages of conjugated cells and more platelets bound per lymphocyte. P-Lym formation initiated by platelet activation was abolished by P-selectin blockade, and tended to be reduced by inhibition of GPIIb/IIIa, CD11b, or CD40L. P-Lym formation initiated by lymphocyte...Continue Reading

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Citations

Aug 6, 2011·Seminars in Immunopathology·Adriana Vieira-de-AbreuGuy A Zimmerman
Jul 7, 2009·Neuromolecular Medicine·Gokhan Yilmaz, D Neil Granger
Mar 1, 2013·Thrombosis and Haemostasis·Nailin Li
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