Platelet-lymphocyte cross-talk

Journal of Leukocyte Biology
N Li

Abstract

Platelets and lymphocytes reciprocally regulate mutual functions, i.e., platelet-lymphocyte cross-talk. The heterotypic interactions have emerged as important regulatory mechanisms in the pathophysiological processes of thrombosis, inflammation, immunity, and atherosclerosis. Platelets influence lymphocyte function via direct cell-cell contact and/or soluble mediators. Hence, platelets enhance adhesion and cell migration of T(H), T cytolytic (T(C)), NK, and B cells. Platelets affect other functional aspects of lymphocyte subpopulations in a complex manner. They may attenuate cytokine secretion and immunosuppressive responses of T(H) cells and enhance T(C) cell proliferation and cytotoxicity. Platelets promote isotype shifting and antibody production of B cells but ameliorate cytolytic activity of NK cells. On the other hand, lymphocytes can also regulate platelet aggregation and secretion, as well as the effector cell function of platelets in immune defense. The two cell types collaborate in transcellular phospholipid metabolism, CD40-CD40 ligand-mediated intercellular signaling, and their involvements in atherogenesis. The research perspectives of platelet-lymphocyte cross-talk have also been addressed.

References

Jul 1, 1992·The Journal of Cell Biology·K L MooreR P McEver
Jul 15, 1992·Biochemical and Biophysical Research Communications·K L Moore, L F Thompson
Nov 1, 1992·Cancer Metastasis Reviews·K V HonnJ D Crissman
Sep 16, 1991·Biochemical and Biophysical Research Communications·N TodorokiT Osawa
Oct 1, 1991·Journal of Immunotherapy·L OleksowiczJ F Holland
Jan 1, 1990·Methods in Enzymology·K K Wu, A C Papp
Aug 1, 1989·The Journal of Clinical Investigation·R L SilversteinR L Nachman
Mar 1, 1986·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·L JonassonG K Hansson
Jan 1, 1987·International Archives of Allergy and Applied Immunology·A CapronC Auriault
Jun 1, 1987·The Journal of Clinical Investigation·K K WuE R Hall
Jul 1, 1987·Annales De L'Institut Pasteur. Immunology·C AuriaultA Capron
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·I R KatzM B Zucker
Apr 1, 1995·British Journal of Haematology·P Lalor, G B Nash
May 1, 1995·International Archives of Allergy and Immunology·P W AskenaseH Matsuda
May 15, 1995·Thrombosis Research·A A SalehE F Mammen
Apr 1, 1994·The Histochemical Journal·K HamamotoK Yasunaga
Mar 1, 1994·Canadian Journal of Physiology and Pharmacology·M A Packham
Jul 12, 1996·Science·T G DiacovoU H von Andrian
Jun 1, 1997·The Journal of Clinical Investigation·S GuptaC Schindler
Feb 7, 1998·The Journal of Experimental Medicine·T G DiacovoU H von Andrian
Jul 3, 1998·The Journal of Clinical Investigation·O P BarryG A FitzGerald
Nov 21, 1998·Cell Adhesion and Communication·U H von Andrian, C M'Rini
Jan 14, 1999·The New England Journal of Medicine·R Ross
Apr 9, 1999·The Journal of Clinical Investigation·D M StafforiniS M Prescott
Sep 24, 1999·Haemostasis·G de GaetanoV Evangelista

❮ Previous
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Citations

Jan 15, 2011·Archivum Immunologiae Et Therapiae Experimentalis·Sonia NéronJean-François Leblanc
Sep 4, 2012·Archivum Immunologiae Et Therapiae Experimentalis·Hsuan-Shun Huang, Hsin-Hou Chang
Aug 6, 2011·Seminars in Immunopathology·Adriana Vieira-de-AbreuGuy A Zimmerman
Jul 7, 2009·Neuromolecular Medicine·Gokhan Yilmaz, D Neil Granger
Jul 4, 2012·Proceedings of the National Academy of Sciences of the United States of America·Giovanni SitiaLuca G Guidotti
Mar 20, 2010·Cardiovascular Research·Stephen F Rodrigues, D Neil Granger
Feb 19, 2011·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Louise BochsenSisse R Ostrowski
Mar 18, 2011·Journal of Innate Immunity·Theresa PlackeHelmut Rainer Salih
Jul 16, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Servio H RamirezYuri Persidsky
Dec 31, 2010·High Altitude Medicine & Biology·Maria A MariggiòFernanda Amicarelli
Dec 21, 2011·The Journal of Physiology·Karen Y Stokes, D Neil Granger
Mar 24, 2012·Archives of Physiology and Biochemistry·James T DixonAndrew M Roberts
Apr 11, 2013·The American Journal of the Medical Sciences·Boris I KuznikEli Magen
Jul 22, 2015·The Journal of Allergy and Clinical Immunology·Chihiro MitsuiMasami Taniguchi
Nov 10, 2015·Clinical Biochemistry·Joanna StępniewskaKazimierz Ciechanowski
Nov 15, 2012·Molecular Immunology·Luca G Guidotti, Matteo Iannacone
Jul 14, 2012·Human Immunology·Hsiao-Hsuan KuoWilliam M Baldwin
Nov 7, 2012·Pulmonary Circulation·Michael H Kroll, Vahid Afshar-Kharghan
Sep 25, 2010·Psychoneuroendocrinology·Anđelko VidovićAnte Sabioncello
Nov 26, 2008·Progress in Cardiovascular Diseases·Bente HalvorsenPål Aukrust
Sep 2, 2008·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·T ChakrounS Yacoub
Jun 3, 2008·Immunology Letters·Yiqiang Wang, Jingyi Niu
Jun 10, 2011·Thrombosis and Haemostasis·Norbert GerdesNailin Li
Apr 24, 2015·Thrombosis and Haemostasis·Waltraud C SchrottmaierAlice Assinger
Sep 16, 2009·Annals of the New York Academy of Sciences·Sansanee NoisakranGuey Chuen Perng
Feb 7, 2009·Journal of Pineal Research·Sergio RegodónJuan A Rosado
Mar 16, 2016·The Pharmacogenomics Journal·A Rivero-JuarezA Rivero
Jul 17, 2010·Journal of Thrombosis and Haemostasis : JTH·B MaîtreC Gachet
Oct 20, 2010·Annals of the New York Academy of Sciences·Guido StollBernhard Nieswandt
Jan 21, 2012·International Journal of Cancer. Journal International Du Cancer·Daniel BuergyMarc A Brockmann
May 31, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Burcin EkserBruno Gridelli
Jul 14, 2010·The Journal of Small Animal Practice·A E RidyardE M Milne
Jul 21, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C C LinD K C Cooper
May 14, 2009·The American Journal of Pathology·Gustavo B MenezesPaul Kubes
Sep 17, 2014·Journal of Thrombosis and Haemostasis : JTH·J M HerterA Zarbock
Mar 13, 2015·Experimental Hematology & Oncology·Antoine DewitteJean Ripoche
Oct 4, 2015·Scandinavian Journal of Medicine & Science in Sports·C MorabitoM A Mariggiò
Sep 12, 2015·International Journal of Cancer. Journal International Du Cancer·Nailin Li

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