PMID: 2835965Jan 1, 1988Paper

Platelet membrane and calcium control abnormalities in essential hypertension

American Journal of Hypertension
F R Bühler, T J Resink

Abstract

The mechanisms whereby intracellular calcium concentration is controlled are briefly reviewed. With the current knowledge of both calcium homeostasis and the function and properties of cellular Ca2+-target proteins/signal transduction systems, a dysfunction of cellular calcium metabolism is considered in relation to the pathogenesis of hypertension. Although the enhanced peripheral vascular resistance characteristic of hypertension is ultimately a function of Ca2+ availability for smooth muscle cell contraction, the platelet possesses many parallel biochemical and physiologic properties. Therefore, we have utilized the platelet as the cell model for investigating the role of Ca2+ in hypertension disorders. An overview of Ca2+-linked platelet processes altered in essential hypertension is presented, and an attempt is made to integrate these multiple aberrations in a fundamental membrane lesion.

Citations

Jan 1, 1989·Clinical and Experimental Hypertension. Part A, Theory and Practice·J de ChamplainR A Nadeau
Jul 13, 2000·Journal of Cardiovascular Pharmacology·F ReisF Teixeira
Jun 5, 2003·Hypertension·Andrew D BlannGregory Y H Lip
Jun 13, 1998·Biochimica Et Biophysica Acta·F C Mooren, R K Kinne
Nov 1, 1996·Metabolism: Clinical and Experimental·S BaldiE Ferrannini

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