PMID: 6743381May 1, 1984Paper

Platelet membrane fluidity and aggregation of rabbit platelets

E BerlinM Friedland


Aggregation of rabbit platelets from citrated plasma in response to ADP was directly correlated with platelet plasma membrane fluidity as determined by fluorescence depolarization measurements with the probe diphenylhexatriene. Rabbits were maintained for periods of 200 and 400 days on potentially hyperlipidemic diets (20% fat by weight) with varying levels of saturated and polyunsaturated fatty acids. Dietary variations were effective in modulating the mole percentage distribution patterns of the platelet phospholipid fatty acids. The major chemical control of membrane fluidity was the actual mass of unsaturated lipid in the cells and not simply the relative percentage distributions of such unsaturated fatty acids. Substantially higher phospholipid/protein ratios were observed upon analysis of platelets and platelet membranes from rabbits after 200- than after 400-day diet periods. Accordingly lipid structures were significantly more fluid in either whole platelets or membrane isolates at the end of the shorter diet period. The observations pertaining to the extent of aggregation and membrane fluidity are in consonance with the general role of membrane fluidity in controlling biological activity and support the concept that pl...Continue Reading


Jan 1, 1988·Molecular and Cellular Biochemistry·B F DickensW B Weglicki
Jan 1, 1987·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·J ThieryD Seidel
Feb 8, 1985·Biochimica Et Biophysica Acta·B P Schick, P K Schick
Aug 8, 1989·Biochimica Et Biophysica Acta·J W HeemskerkG Hornstra
Sep 1, 1989·Journal of the Neurological Sciences·C HübnerA Kohlschütter
Dec 1, 1986·Mechanisms of Ageing and Development·D Kasjanovová, V Baláz
Jan 1, 1991·Comparative Biochemistry and Physiology. A, Comparative Physiology·E BerlinC Young
Jan 1, 1993·General Pharmacology·J PetrusewiczH Foks
Oct 20, 1998·Prostaglandins & Other Lipid Mediators·M M Mahfouz, F A Kummerow
Dec 24, 2013·Journal of Cardiovascular Translational Research·José Luis FerreiroAngel Cequier
Jul 1, 1987·Progress in Cardiovascular Diseases·M Aviram, J G Brook
Apr 1, 1989·Metabolism: Clinical and Experimental·M Aviram, R J Deckelbaum
Mar 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J J BadimonV Fuster
May 1, 1997·European Journal of Haematology·B WalkowiakC S Cierniewski
May 1, 1993·Scandinavian Journal of Clinical and Laboratory Investigation·P FalkeL Stavenow
Aug 1, 1989·Metabolism: Clinical and Experimental·E BerlinP R Taylor

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.