Platelet mitochondrial activity and pesticide exposure in early Parkinson's disease

Movement Disorders : Official Journal of the Movement Disorder Society
J BronsteinBeate Ritz

Abstract

Mitochondrial dysfunction has been implicated in the pathogenesis of Parkinson's disease (PD), but the cause of this dysfunction is unclear. Platelet mitochondrial complex I and I/III (nicotinamide adenine dinucleotide cytochrome c reductase, NCCR) activities were measured in early PD patients and matched controls enrolled in a population-based case-control study. Ambient agricultural pesticide exposures were assessed with a geographic information system and California Pesticide Use Registry. In contrast to some previous reports, we found no differences in complex I and I/III activities in subjects with PD and controls. We did find that NCCR activity correlated with subjects' exposure to pesticides known to inhibit mitochondrial activity regardless of their diagnosis. Electron transport chain (ETC) activity is not altered in PD in this well-characterized cohort when compared with community-matched controls but appears to be affected by environmental toxins, such as mitochondria-inhibiting pesticides.

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Citations

Oct 22, 2017·Biochemical Society Transactions·Li WangYuan Lu
Jan 30, 2019·Frontiers in Neurology·Domenico PlantoneTatiana Koudriavtseva
Mar 25, 2019·Physiological Research·A T PetrusI Ionită
Dec 10, 2019·Biological Chemistry·Bradford G HillVictor M Darley-Usmar
Jun 2, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·L HolperJ J Mann
May 21, 2020·Frontiers in Immunology·Odette Leiter, Tara L Walker
Nov 26, 2020·International Journal of Molecular Sciences·Benedetta IzziAlessandro Gialluisi

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