Platelet mitochondrial dysfunction and mitochondria-targeted quinone-and hydroquinone-derivatives: Review on new strategy of antiplatelet activity

Biochemical Pharmacology
Manuel FuentesEduardo Fuentes

Abstract

Platelet mitochondrial dysfunction has been identified in different diseases. Platelet mitochondrial dysfunction favors platelet activation with a considerable increase in oxidative stress, which is implicated in platelet non-responsiveness to current antiplatelet therapy. The inhibition of platelet mitochondrial dysfunction could potentially be used as a new strategy for the development of antiplatelet activity drugs. In this context, we described quinone and hydroquinone derivatives and mitochondrially targeted compounds as initial precursors for the synthesis of new antiplatelet agents.

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Citations

Feb 5, 2019·Journal of Cellular Physiology·Xu-Ling LuoLin-Xi Chen
Jan 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maximiliano Martínez-CifuentesRamiro Araya-Maturana

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