PMID: 2498457Jan 1, 1989Paper

Platelet-modified low density lipoprotein induces macrophage cholesterol accumulation and platelet activation

Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie
M AviramG J Brook

Abstract

Low density lipoprotein (LDL), modified by chemical or biological means, was shown to induce macrophage cholesterol accumulation. The cholesterol and protein contents of LDL were decreased (by 10 and 15%, respectively) by incubation of the LDL for 2 h at 37 degrees C with normal washed platelet suspension or with platelet-conditioned medium; these decreases were not affected by platelet activation. The platelet-modified LDL caused a greater increase (by up to 15%) in collagen-induced, in vitro platelet aggregation than control LDL. Incubation of mouse peritoneal macrophages with platelet-modified LDL for 18 h at 37 degrees C resulted in an elevation of the macrophage cholesterol ester content (by 35-50%) as well as an increase in the cholesterol esterification rate (by 40-70%), compared with the effect of control LDL. Macrophage cholesterol synthesis, however, was significantly decreased (by 40-50%), compared with the effect of control LDL. The effect of LDL treated by platelet-conditioned medium was similar to that of platelet-modified LDL. The effect of platelet-modified LDL on macrophage cholesterol esterification was maximal within 24 h of incubation, and it was not significantly affected by inhibition of cholesterol synthe...Continue Reading

References

Sep 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·S K BasuM S Brown
Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J L GoldsteinM S Brown
Feb 20, 1986·The New England Journal of Medicine·R Ross
Nov 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·J L GoldsteinM S Brown
Jul 1, 1983·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·D Steinberg
May 1, 1983·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·P W WilsonW P Castelli
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·A M FogelmanP A Edwards
Mar 1, 1983·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·T HenriksenD Steinberg
Sep 1, 1981·The American Journal of Medicine·B B Weksler, R L Nachman

❮ Previous
Next ❯

Citations

Nov 13, 2014·Hormone Molecular Biology and Clinical Investigation·Antonio López FarréJosé J Zamorano-León
Jun 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J Oiknine, M Aviram
Jul 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M AviramJ G Brook

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.