Platelet monoamine oxidase in Parkinson patients: effect of L-deprenyl therapy

Journal of Neural Transmission. Parkinson's Disease and Dementia Section
D H LeeM D Yahr

Abstract

Platelet MAO activity was measured in 79 Parkinson patients (56 males and 23 females) before and during L-deprenyl therapy. Baseline platelet MAO activity was higher in females than in males with no age dependent differences. During chronic L-deprenyl therapy, MAO activity was inhibited greater than 98%. Four hours after the oral administration of the first 5 mg dose of L-deprenyl, platelet MAO activity was inhibited by 86%. By 24 hours, greater than 98% inhibition was achieved and this degree of inhibition was maintained during continuous L-deprenyl administration. Following oral administration of 10 mg L-deprenyl once a day versus 5 mg L-deprenyl twice a day, the time course of platelet MAO inhibition was similar. Five days after the termination of chronic L-deprenyl therapy, platelet MAO activity was still inhibited by 96%. MAO activity returned to normal by 2 weeks after stopping L-deprenyl. Platelet MAO activity is a useful method of monitoring bioavailability, compliance, dose-response relationship and optimal dosage schedules for L-deprenyl in Parkinson patients.

References

Dec 1, 1978·British Journal of Clinical Pharmacology·G P ReynoldsG M Stern
Jan 1, 1978·Journal of Neural Transmission·P RiedererD Seemann
Jan 1, 1978·Journal of Neural Transmission·M D Yahr
Jan 6, 1977·Nature·V GloverG J Riley
Jul 1, 1968·Biochemical Pharmacology·J P Johnston
Nov 1, 1965·Biochemical Pharmacology·M Krajl
Jan 1, 1983·Acta Neurologica Scandinavica. Supplementum·L OrelandJ Ekstedt
Jan 15, 1984·Biochemical Pharmacology·C H Williams
Jan 1, 1980·Journal of Neural Transmission·C J FowlerB Winblad

❮ Previous
Next ❯

Citations

May 1, 1997·Movement Disorders : Official Journal of the Movement Disorder Society·N AndreuJ L Montastruc
Jan 1, 1994·International Archives of Occupational and Environmental Health·H CheckowayL G Costa
Mar 1, 1992·Italian Journal of Neurological Sciences·G FinaliG L Piccinin
Jan 1, 1992·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·H CheckowayP D Swanson
Apr 27, 2001·Toxicology Letters·A G Renwick, K Walton
Jan 1, 1991·Acta Neurologica Scandinavica. Supplementum·E H Heinonen, R Lammintausta
Oct 1, 1990·Journal of Neurology, Neurosurgery, and Psychiatry·U BonuccelliA Muratorio
Mar 5, 2009·Neurochemical Research·Maroof HusainVinay K Khanna
Jul 15, 1998·British Journal of Clinical Pharmacology·P BitsiosC M Bradshaw
Feb 6, 2007·Environmental Monitoring and Assessment·Virginia D EnglePete Bourgeois
Jan 1, 1992·Scandinavian Journal of Gastroenterology. Supplement·A Garner
Aug 26, 1998·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·W KuhnM E Goetz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.