Platelet-monocyte interaction in Mycobacterium tuberculosis infection

Tuberculosis
Vesla KullayaQuirijn de Mast

Abstract

The immune effects of platelets and platelet-leukocyte aggregation are increasingly recognized. We studied the occurrence of platelet-monocyte aggregation (PMA) in patients with pulmonary tuberculosis (TB), the processes underlying PMA and consequences for cytokine responses. In a cross-sectional study involving 65 Tanzanian TB patients in different phases of treatment and 29 healthy controls, TB patients had a significantly higher PMA. This increased PMA in TB patients was associated with increased monocyte CCR5, CD16 expression and PF4, but not with increased membrane-expressed or soluble P-selectin expression. These findings were confirmed in vitro: whereas incubation of whole blood with Mycobacterium tuberculosis (Mtb) did not activate platelets, monocytes became activated with higher CD11b, CD16 and CCR5 expression, but this was independent of platelet-monocyte interaction. Still, platelets had an anti-inflammatory effect on cytokine responses as peripheral blood mononuclear cells (PBMC) incubated with Mtb in the presence of platelets produced less interleukin (IL)-1β, tumor necrosis factor-α, IL-6 and interferon-γ and more IL-10. In conclusion, increased PMA during TB infection is caused by monocyte and not platelet activ...Continue Reading

Citations

Mar 17, 2019·The Journal of Infectious Diseases·Elinor HortleStefan H Oehlers
Mar 10, 2020·Pathogens and Disease·Elinor Hortle, Stefan H Oehlers
May 19, 2020·American Journal of Respiratory and Critical Care Medicine·Lisa ScheuermannAnca Dorhoi
May 7, 2019·Frontiers in Cellular and Infection Microbiology·Shyamala Thirunavukkarasu, Shabaana A Khader
Feb 2, 2021·Microbial Pathogenesis·Flor Torres-JuarezBruno Rivas-Santiago
Jun 8, 2021·Frontiers in Immunology·Daniela E KirwanJon S Friedland

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