Platelet noradrenaline release in patients with familial hypercholesterolaemia

European Journal of Clinical Investigation
C C SmithD J Betteridge

Abstract

We have examined resting and thrombin (0.3 units ml-1) induced release of noradrenaline by washed platelets from 15 normal subjects and eight patients with heterozygous familial hypercholesterolaemia. Platelets from both normal and hypercholesterolaemic subjects showed irreversible aggregation with 0.3 units ml-1 thrombin. Extents of aggregation were 76.3% and 90.8% respectively, platelets from hypercholesterolaemic patients being significantly more sensitive (P less than 0.002). Under resting conditions platelet noradrenaline release was 136% greater (P less than 0.02) in hypercholesterolaemic patients than in normal subjects. Thrombin-stimulated release of noradrenaline was also higher (73%, P less than 0.05) in hypercholesterolaemics than in normals. The differences between resting and thrombin-stimulated release were greater for hypercholesterolaemic patients than normal subjects (P less than 0.05). Under resting conditions total platelet noradrenaline levels (sum of supernatant and platelet pellet concentrations) were similar in preparations from the two groups. However, following thrombin stimulation total noradrenaline concentrations were substantially greater (86%) in platelets from hypercholesterolaemics than normals (...Continue Reading

References

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Citations

Apr 1, 1997·Atherosclerosis·C C Smith, D J Betteridge
Dec 1, 1990·Baillière's Clinical Endocrinology and Metabolism·J A Gasser, D J Betteridge
Feb 1, 1994·European Journal of Clinical Investigation·D J BetteridgeC C Smith
Aug 29, 1996·Biochimica Et Biophysica Acta·C C Smith

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