Platelet packing density is an independent regulator of the hemostatic response to injury.

Journal of Thrombosis and Haemostasis : JTH
M MirramezaniMaurizio Tomaiuolo

Abstract

Essentials Platelet packing density in a hemostatic plug limits molecular movement to diffusion. A diffusion-dependent steep thrombin gradient forms radiating outwards from the injury site. Clot retraction affects the steepness of the gradient by increasing platelet packing density. Together, these effects promote hemostatic plug core formation and inhibit unnecessary growth. Background Hemostasis studies performed in vivo have shown that hemostatic plugs formed after penetrating injuries are characterized by a core of highly activated, densely packed platelets near the injury site, covered by a shell of less activated and loosely packed platelets. Thrombin production occurs near the injury site, further activating platelets and starting the process of platelet mass retraction. Tightening of interplatelet gaps may then prevent the escape and exchange of solutes. Objectives To reconstruct the hemostatic plug macro- and micro-architecture and examine how platelet mass contraction regulates solute transport and solute concentration in the gaps between platelets. Methods Our approach consisted of three parts. First, platelet aggregates formed in vitro under flow were analyzed using scanning electron microscopy to extract data on po...Continue Reading

References

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Citations

Dec 27, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Andaleb Kholmukhamedov, Shawn Jobe
May 9, 2019·Computer Methods in Biomechanics and Biomedical Engineering·Hari Hara Sudhan LakshmananJeevan Maddala
May 20, 2020·Platelets·Maurizio TomaiuoloTimothy J Stalker
Sep 12, 2020·Hämostaseologie·Dmitry Y NechipurenkoMikhail A Panteleev
May 22, 2020·Nature Reviews. Materials·Yongzhi QiuWilbur A Lam
Mar 29, 2018·Journal of Thrombosis and Thrombolysis·Michal ZabczykAnetta Undas
Jan 14, 2021·Biomechanics and Modeling in Mechanobiology·Chayut TeeraratkulDebanjan Mukherjee
May 27, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·Monica A BrayRolando E Rumbaut
Sep 4, 2021·Journal of Biomechanics·Chayut Teeraratkul, Debanjan Mukherjee
Sep 24, 2021·Journal of Veterinary Emergency and Critical Care·Johnson ChangMichael S Kent

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