Platelet parameters (PLT, MPV, P-LCR) in patients with schizophrenia, unipolar depression and bipolar disorder

Psychiatry Research
Adam Wysokiński, Ewa Szczepocka

Abstract

There are no studies comparing platelet parameters platelet parameters (platelet count (PLT), mean platelet volume (MPV) and platelet large cell ratio (P-LCR)) between patients with schizophrenia, bipolar disorder and unipolar depression. Therefore, the aim of this study was to determine and compare differences in PLT, MPV and P-LCR in patients with schizophrenia, unipolar depression and bipolar disorder. This was a retrospective, cross-sectional, naturalistic study of 2377 patients (schizophrenia n=1243; unipolar depression n=791; bipolar disorder n=343, including bipolar depression n=259 and mania n=84). There were significant differences for PLT, MPV and P-LCR values between study groups. A significant percentage of patients with bipolar disorder had abnormal (too low or too high) number of platelets. Negative correlation between PLT and age was found in all study groups and positive correlation between age and MPV and P-LCR was found in patients with schizophrenia.

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Citations

Oct 13, 2018·Journal of Immunoassay & Immunochemistry·Mehmet Hamdi OrumOguzhan Bekir Egilmez
Feb 27, 2019·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Mario Gennaro MazzaMassimo Clerici
Sep 9, 2020·Psychiatry Investigation·Yasin Hasan Balcioglu, Simge Seren Kirlioglu
Feb 9, 2017·Journal of Clinical Laboratory Analysis·Derya GuzelAtila Erol
Nov 26, 2020·International Journal of Molecular Sciences·Benedetta IzziAlessandro Gialluisi
Oct 31, 2020·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Qi YuYong Liu
Jun 13, 2021·Neuroscience and Biobehavioral Reviews·Gerwyn MorrisBasant K Puri

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