PMID: 6105392Aug 2, 1980Paper

Platelet protection and heparin sparing with prostacyclin during regular dialysis therapy

Lancet
J H TurneyM J Weston

Abstract

When prostacyclin (5 ng kg-1 min-1) was given during dialysis it enhanced the biological activity of heparin and prevented the activation and consumption of platelets. No adverse effects were observed. The reduction in heparin requirements produced by prostacyclin should make dialysis, safer, particularly for patients at risk of bleeding, while preserving the biocompatibility of the dialysis circuit. It remains to be established whether prevention of platelet activation will confer long-term benefit by inhibiting the prothrombotic state induced by haemodialysis, thereby reducing the risk of atherosclerosis in uraemic patients.

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Citations

Jan 1, 1991·Intensive Care Medicine·T Wetterberg, S Steen
Jan 1, 1983·Intensive Care Medicine·M T Weston
Jan 1, 1991·International Urology and Nephrology·M KuźniewskiJ Lisiewicz
Jan 1, 1992·International Urology and Nephrology·M Kuźniewski, W Sułowicz
Jun 1, 1981·Prostaglandins·M GrossW Flamenbaum
Jul 4, 1981·Lancet·S B JanvrinR M Greenhalgh
Jul 4, 1981·Lancet·R S Arze, M K Ward
Sep 11, 1982·Lancet·M J WestonJ O'Grady
Apr 16, 1981·The New England Journal of Medicine·R M ZusmanN Tolkoff-Rubin
Feb 3, 1983·The New England Journal of Medicine·R V PinnickD A Diederich
May 23, 1981·British Medical Journal·J H TurneyM J Weston
Mar 1, 1994·Postgraduate Medical Journal·G WoodrowJ H Turney
Aug 1, 1985·British Journal of Haematology·F E Preston, M Greaves
Oct 1, 1987·Kidney International·H BernsteinR Langer
Mar 29, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Juliane K UngerRolf Rossaint
Jan 12, 2000·Current Opinion in Nephrology and Hypertension·S Abramson, J L Niles
Aug 1, 1982·British Journal of Clinical Pharmacology·H Pickles, J O'Grady
Jan 1, 1984·Acta Medica Scandinavica·T Wessel-AasT Nilsen
Apr 1, 1985·Klinische Wochenschrift·M GoerigG Schettler
Dec 1, 1982·Postgraduate Medicine·O I Linet
Jan 1, 1991·Platelets·M P Gordge, G H Neild
Jan 1, 1983·British Journal of Clinical Pharmacology·N J DoddM J Weston
Jun 2, 2000·Seminars in Dialysis·R Ouseph, R A Ward
Nov 7, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Meiwen DingNisanne S Ghonem
May 1, 1983·The Annals of Thoracic Surgery·G M PalatianosL W Stephenson

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