PMID: 2119633Jan 1, 1990Paper

Platelet reactivity and arachidonic acid metabolism in type II hyperlipoproteinaemia and its modification by cholesterol-lowering agents

Eicosanoids
K Schrör

Abstract

A significant percentage of patients suffering from a selective increase in plasma LDL cholesterol (type IIa hyperlipoproteinaemia) exhibits increased platelet reactivity. This includes enhanced platelet responsiveness against a variety of platelet-stimulating agents ex vivo and enhanced arachidonic acid metabolism associated with increased generation of arachidonic acid metabolites (thromboxane A2, 12-HETE) and secretion of platelet-storage products. It is possible, but not proven, that an elevated cholesterol content in the platelet membranes forms a common denominator for these responses. Agents that lower total plasma or LDL cholesterol in hypercholesterolaemic patients by interfering with cholesterol reabsorption from the gut (cholestyramine, cholestipol) or reduction of hepatic VLDL release (fibrates) do not appear to interfere with platelet hyperreactivity and do not change platelet-derived thromboxane formation. There is also no correlation with the action of these agents on total plasma and LDL cholesterol. A different situation might exist with inhibitors of the HMG-CoA reductase, which have been found to reduce platelet hyperreactivity and thromboxane formation. However, this finding requires further confirmation in ...Continue Reading

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