Platelet-rich fibrin with 1% metformin for the treatment of intrabony defects in chronic periodontitis: a randomized controlled clinical trial

Journal of Periodontology
A R PradeepC N Guruprasad

Abstract

Platelet-rich fibrin (PRF) is a second-generation platelet concentrate that releases various growth factors that promote tissue regeneration. Metformin (MF), a member of the biguanide group, has been shown to facilitate osteoblast differentiation and thus may exhibit a favorable effect on alveolar bone. The current study is designed to evaluate the efficacy of open-flap debridement (OFD) combined with PRF, 1% MF gel, and PRF + 1% MF gel in the treatment of intrabony defects (IBDs) in patients with chronic periodontitis (CP). One hundred twenty patients with single defects were categorized into four treatment groups: OFD alone, OFD with PRF, OFD with 1% MF, and OFD with PRF plus 1% MF. Clinical parameters such as site-specific plaque index (PI), modified sulcus bleeding index (mSBI), probing depth (PD), relative attachment level (RAL), and gingival marginal level (GML) were recorded at baseline (before surgery) and 9 months postoperatively. Percentage radiographic IBD depth reduction was evaluated using computer-aided software at baseline and 9 months. PRF, 1% MF, and PRF + 1% MF groups showed significantly more PD reduction and RAL gain than the OFD-only group. Mean PD reduction and mean RAL gain were found to be greater in the...Continue Reading

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Citations

Mar 7, 2017·Journal of Clinical Periodontology·Huseyin Gencay KeceliHumerya Aydemir Turkal
Nov 24, 2018·Diabetes/metabolism Research and Reviews·Evangelia KalaitzoglouKathryn M Thrailkill
Nov 23, 2018·Drug Delivery and Translational Research·Suping WangHockin H K Xu
Apr 3, 2019·The International Journal of Artificial Organs·Daniela CarmagnolaElena Varoni
Apr 11, 2019·Brazilian Dental Journal·Luiz Alexandre ChisiniFlávio Fernando Demarco
Dec 15, 2019·International Journal of Molecular Sciences·Tulio Fernández-MedinaSašo Ivanovski
May 30, 2017·Clinical Oral Investigations·Richard J MironJoseph Choukroun
Feb 2, 2019·Journal of Bone and Mineral Metabolism·Jianrong ZhaoLi Zuo
Sep 13, 2017·Tissue Engineering and Regenerative Medicine·Shariq NajeebJukka Pekka Matinlinna
Nov 30, 2018·The Cochrane Database of Systematic Reviews·Massimo Del FabbroSilvio Taschieri
Jan 23, 2021·Journal of Personalized Medicine·Yu Gyung KimDo-Yeon Kim
Oct 9, 2018·Journal of Endodontics·Eddie Hsiang-Hua LaiJenny Zwei-Chieng Chang

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