Platelet-rich plasma and regenerative dentistry

Australian Dental Journal
J XuS Qiu

Abstract

Regenerative dentistry is an emerging field of medicine involving stem cell technology, tissue engineering and dental science. It exploits biological mechanisms to regenerate damaged oral tissues and restore their functions. Platelet-rich plasma (PRP) is a biological product that is defined as the portion of plasma fraction of autologous blood with a platelet concentration above that of the original whole blood. A super-mixture of key cytokines and growth factors is present in platelet granules. Thus, the application of PRP has gained unprecedented attention in regenerative medicine. The rationale underlies the utilization of PRP is that it acts as a biomaterial to deliver critical growth factors and cytokines from platelet granules to the targeted area, thus promoting regeneration in a variety of tissues. Based on enhanced understanding of cell signalling and growth factor biology, researchers have begun to use PRP treatment as a novel method to regenerate damaged tissues, including liver, bone, cartilage, tendon and dental pulp. To enable better understanding of the regenerative effects of PRP in dentistry, this review describes different methods of preparation and application of this biological product, and provides detailed...Continue Reading

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Citations

Oct 25, 2020·International Journal of Molecular Sciences·Peter EvertsKenneth Mautner
Jan 23, 2021·International Journal of Molecular Sciences·Magdalena MisiuraWojciech Miltyk
May 1, 2021·International Journal of Molecular Sciences·Sahng G Kim
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May 9, 2021·Human Reproduction·Lloyd AtkinsonRoger G Sturmey
Jun 3, 2021·Materials·Mihaela OlaruGabriela Calin

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